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General | Insiders | Insider Transactions | Monthly Overview | Weekly Overview

Overview of all insider trading transactions in Orexigen Therapeutics, Inc.. Get notifications about new insider transactions in Orexigen Therapeutics, Inc. for free.

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Date	Ticker	Company	Owner	Relationship	Transaction	Code	Cost ($)	Shares	Transaction Value ($)	Total Shares	% Holdings
Aug 29 2008	OREX	Orexigen Therapeut ...	MCKINNEY ANTHONY A	Chief Business Offi ...	Option Exercise	M	0.10	13,664	1,366	122,291
Aug 29 2008	OREX	Orexigen Therapeut ...	MCKINNEY ANTHONY A	Chief Business Offi ...	Sell	S	12.00	13,664	163,968	0	13.7 K to 0 (-100.00 %)
Aug 29 2008	OREX	Orexigen Therapeut ...	MCKINNEY ANTHONY A	Chief Business Offi ...	Buy	M	0.10	13,664	1,366	13,664	0 to 13.7 K
Aug 29 2008	OREX	Orexigen Therapeut ...	POWELL MICHAEL	Director	Sell	S	12.05	100	1,205	31,255	31.4 K to 31.3 K (-0.32 %)
Aug 29 2008	OREX	Orexigen Therapeut ...	POWELL MICHAEL	Director	Sell	S	12.05	200	2,410	31,355	31.6 K to 31.4 K (-0.63 %)
Aug 29 2008	OREX	Orexigen Therapeut ...	POWELL MICHAEL	Director	Sell	S	12.05	1,800	21,682	454,848	456.6 K to 454.8 K (-0.39 %)
Aug 29 2008	OREX	Orexigen Therapeut ...	POWELL MICHAEL	Director	Sell	S	12.05	3,300	39,772	456,648	459.9 K to 456.6 K (-0.72 %)
Aug 29 2008	OREX	Orexigen Therapeut ...	POWELL MICHAEL	Director	Sell	S	12.05	8,900	107,205	2,295,851	2.3 M to 2.3 M (-0.39 %)
Aug 29 2008	OREX	Orexigen Therapeut ...	POWELL MICHAEL	Director	Sell	S	12.05	16,500	198,858	2,304,751	2.3 M to 2.3 M (-0.71 %)
Aug 27 2008	OREX	Orexigen Therapeut ...	MCKINNEY ANTHONY A	Chief Business Offi ...	Option Exercise	M	0.10	3,000	300	135,955
Aug 27 2008	OREX	Orexigen Therapeut ...	MCKINNEY ANTHONY A	Chief Business Offi ...	Sell	S	12.02	3,000	36,060	0	3 K to 0 (-100.00 %)
Aug 27 2008	OREX	Orexigen Therapeut ...	MCKINNEY ANTHONY A	Chief Business Offi ...	Buy	M	0.10	3,000	300	3,000	0 to 3 K
Aug 27 2008	OREX	Orexigen Therapeut ...	LANDBLOOM RONALD P	VP, Medical and Reg ...	Option Exercise	M	2.00	40,000	80,000	200,000
Aug 27 2008	OREX	Orexigen Therapeut ...	LANDBLOOM RONALD P	VP, Medical and Reg ...	Sell	S	11.28	40,000	451,200	0	40 K to 0 (-100.00 %)
Aug 27 2008	OREX	Orexigen Therapeut ...	LANDBLOOM RONALD P	VP, Medical and Reg ...	Buy	M	2.00	40,000	80,000	40,000	0 to 40 K
Aug 25 2008	OREX	Orexigen Therapeut ...	BYMASTER FRANKLIN P	VP, Neuroscience	Option Exercise	M	2.00	1,800	3,600	19,959
Aug 25 2008	OREX	Orexigen Therapeut ...	BYMASTER FRANKLIN P	VP, Neuroscience	Option Exercise	M	2.00	3,241	6,482	21,759
Aug 25 2008	OREX	Orexigen Therapeut ...	BYMASTER FRANKLIN P	VP, Neuroscience	Sell	S	12.00	1,800	21,600	0	1.8 K to 0 (-100.00 %)
Aug 25 2008	OREX	Orexigen Therapeut ...	BYMASTER FRANKLIN P	VP, Neuroscience	Buy	M	2.00	1,800	3,600	1,800	0 to 1.8 K
Aug 25 2008	OREX	Orexigen Therapeut ...	BYMASTER FRANKLIN P	VP, Neuroscience	Sell	S	12.00	3,241	38,892	0	3.2 K to 0 (-100.00 %)
Aug 25 2008	OREX	Orexigen Therapeut ...	BYMASTER FRANKLIN P	VP, Neuroscience	Buy	M	2.00	3,241	6,482	3,241	0 to 3.2 K
Aug 25 2008	OREX	Orexigen Therapeut ...	COOPER GRAHAM K	CFO and Treasurer	Option Exercise	M	0.70	8,259	5,781	246,685
Aug 25 2008	OREX	Orexigen Therapeut ...	COOPER GRAHAM K	CFO and Treasurer	Sell	S	12.00	8,259	99,108	0	8.3 K to 0 (-100.00 %)
Aug 25 2008	OREX	Orexigen Therapeut ...	COOPER GRAHAM K	CFO and Treasurer	Buy	M	0.70	8,259	5,781	8,259	0 to 8.3 K
Aug 25 2008	OREX	Orexigen Therapeut ...	DUNAYEVICH EDUARDO	Chief Medical Offic ...	Option Exercise	M	2.00	8,259	16,518	231,741
Aug 25 2008	OREX	Orexigen Therapeut ...	DUNAYEVICH EDUARDO	Chief Medical Offic ...	Sell	S	12.00	8,259	99,108	0	8.3 K to 0 (-100.00 %)
Aug 25 2008	OREX	Orexigen Therapeut ...	DUNAYEVICH EDUARDO	Chief Medical Offic ...	Buy	M	2.00	8,259	16,518	8,259	0 to 8.3 K
Aug 25 2008	OREX	Orexigen Therapeut ...	POWELL MICHAEL	Director	Sell	S	12.00	100	1,200	31,555	31.7 K to 31.6 K (-0.32 %)
Aug 25 2008	OREX	Orexigen Therapeut ...	POWELL MICHAEL	Director	Sell	S	12.00	100	1,200	31,655	31.8 K to 31.7 K (-0.31 %)
Aug 25 2008	OREX	Orexigen Therapeut ...	POWELL MICHAEL	Director	Sell	S	12.00	800	9,602	459,948	460.7 K to 459.9 K (-0.17 %)
Aug 25 2008	OREX	Orexigen Therapeut ...	POWELL MICHAEL	Director	Sell	S	12.00	800	9,600	460,748	461.5 K to 460.7 K (-0.17 %)
Aug 25 2008	OREX	Orexigen Therapeut ...	POWELL MICHAEL	Director	Sell	S	12.00	3,900	46,810	2,321,251	2.3 M to 2.3 M (-0.17 %)
Aug 25 2008	OREX	Orexigen Therapeut ...	POWELL MICHAEL	Director	Sell	S	12.00	4,400	52,800	2,325,151	2.3 M to 2.3 M (-0.19 %)
Aug 18 2008	OREX	Orexigen Therapeut ...	LANDBLOOM RONALD P	VP, Medical and Reg ...	Option Exercise	A	11.34	40,000	453,600	40,000
Aug 18 2008	OREX	Orexigen Therapeut ...	BYMASTER FRANKLIN P	VP, Neuroscience	Option Exercise	A	11.34	10,000	113,400	10,000
Aug 18 2008	OREX	Orexigen Therapeut ...	Turner Heather D	VP, Gen. Counsel & ...	Option Exercise	A	11.34	100,000	1,134,000	100,000
Aug 18 2008	OREX	Orexigen Therapeut ...	COWLEY MICHAEL A	Chief Scientific Of ...	Option Exercise	A	11.34	25,000	283,500	25,000
Aug 18 2008	OREX	Orexigen Therapeut ...	DUNAYEVICH EDUARDO	Chief Medical Offic ...	Option Exercise	A	11.34	120,000	1,360,800	120,000
Aug 18 2008	OREX	Orexigen Therapeut ...	MCKINNEY ANTHONY A	Chief Business Offi ...	Option Exercise	A	11.34	50,000	567,000	50,000
Aug 18 2008	OREX	Orexigen Therapeut ...	COOPER GRAHAM K	CFO and Treasurer	Option Exercise	A	11.34	110,000	1,247,400	110,000
Aug 18 2008	OREX	Orexigen Therapeut ...	TOLLEFSON GARY D	President and CEO	Option Exercise	A	11.34	310,000	3,515,400	310,000
Jun 13 2008	OREX	Orexigen Therapeut ...	BOCK LOUIS C	Director	Option Exercise	A	8.18	25,000	204,500	25,000
Jun 12 2008	OREX	Orexigen Therapeut ...	WEBER ECKARD	Director	Option Exercise	A	8.18	25,000	204,500	25,000
Jun 12 2008	OREX	Orexigen Therapeut ...	DOVEY BRIAN H	Director	Option Exercise	A	8.18	25,000	204,500	25,000
Jun 12 2008	OREX	Orexigen Therapeut ...	LACOB JOSEPH	Director	Option Exercise	A	8.18	25,000	204,500	25,000
Jun 12 2008	OREX	Orexigen Therapeut ...	POWELL MICHAEL	Director	Option Exercise	A	8.18	25,000	204,500	25,000
Jun 12 2008	OREX	Orexigen Therapeut ...	TURNER DANIEL K III	Director	Option Exercise	A	8.18	25,000	204,500	25,000
Dec 28 2007	OREX	Orexigen Therapeut ...	LANCASTER JAMES C JR	VP of Commercial Op ...	Option Exercise	M	2.00	3,000	6,000	31,500
Dec 28 2007	OREX	Orexigen Therapeut ...	LANCASTER JAMES C JR	VP of Commercial Op ...	Sell	S	15.10	500	7,550	0	500 to 0 (-100.00 %)
Dec 28 2007	OREX	Orexigen Therapeut ...	LANCASTER JAMES C JR	VP of Commercial Op ...	Sell	S	15.07	19	286	500	519 to 500 (-3.66 %)
Dec 28 2007	OREX	Orexigen Therapeut ...	LANCASTER JAMES C JR	VP of Commercial Op ...	Sell	S	15.05	481	7,239	519	1,000 to 519 (-48.10 %)
Dec 28 2007	OREX	Orexigen Therapeut ...	LANCASTER JAMES C JR	VP of Commercial Op ...	Sell	S	15.00	542	8,130	1,000	1.5 K to 1,000 (-35.15 %)
Dec 28 2007	OREX	Orexigen Therapeut ...	LANCASTER JAMES C JR	VP of Commercial Op ...	Sell	S	14.90	1,458	21,724	1,542	3 K to 1.5 K (-48.60 %)
Dec 28 2007	OREX	Orexigen Therapeut ...	LANCASTER JAMES C JR	VP of Commercial Op ...	Buy	M	2.00	3,000	6,000	3,000	0 to 3 K
Dec 28 2007	OREX	Orexigen Therapeut ...	LANDBLOOM RONALD P	VP, Medical and Reg ...	Option Exercise	M	2.00	5,000	10,000	240,000
Dec 28 2007	OREX	Orexigen Therapeut ...	LANDBLOOM RONALD P	VP, Medical and Reg ...	Sell	S	15.10	820	12,382	0	820 to 0 (-100.00 %)
Dec 28 2007	OREX	Orexigen Therapeut ...	LANDBLOOM RONALD P	VP, Medical and Reg ...	Sell	S	15.07	32	482	820	852 to 820 (-3.76 %)
Dec 28 2007	OREX	Orexigen Therapeut ...	LANDBLOOM RONALD P	VP, Medical and Reg ...	Sell	S	15.05	788	11,859	852	1.6 K to 852 (-48.05 %)
Dec 28 2007	OREX	Orexigen Therapeut ...	LANDBLOOM RONALD P	VP, Medical and Reg ...	Sell	S	15.00	888	13,320	1,640	2.5 K to 1.6 K (-35.13 %)
Dec 28 2007	OREX	Orexigen Therapeut ...	LANDBLOOM RONALD P	VP, Medical and Reg ...	Sell	S	14.90	2,472	36,833	2,528	5 K to 2.5 K (-49.44 %)
Dec 28 2007	OREX	Orexigen Therapeut ...	LANDBLOOM RONALD P	VP, Medical and Reg ...	Buy	M	2.00	5,000	10,000	5,000	0 to 5 K
Dec 28 2007	OREX	Orexigen Therapeut ...	MCKINNEY ANTHONY A	Chief Operating Off ...	Option Exercise	M	0.10	4,166	417	138,955
Dec 28 2007	OREX	Orexigen Therapeut ...	MCKINNEY ANTHONY A	Chief Operating Off ...	Sell	S	15.10	680	10,268	0	680 to 0 (-100.00 %)
Dec 28 2007	OREX	Orexigen Therapeut ...	MCKINNEY ANTHONY A	Chief Operating Off ...	Sell	S	15.07	27	407	680	707 to 680 (-3.82 %)
Dec 28 2007	OREX	Orexigen Therapeut ...	MCKINNEY ANTHONY A	Chief Operating Off ...	Sell	S	15.05	653	9,828	707	1.4 K to 707 (-48.01 %)
Dec 28 2007	OREX	Orexigen Therapeut ...	MCKINNEY ANTHONY A	Chief Operating Off ...	Sell	S	15.00	736	11,040	1,360	2.1 K to 1.4 K (-35.11 %)
Dec 28 2007	OREX	Orexigen Therapeut ...	MCKINNEY ANTHONY A	Chief Operating Off ...	Sell	S	14.90	2,070	30,843	2,096	4.2 K to 2.1 K (-49.69 %)
Dec 28 2007	OREX	Orexigen Therapeut ...	MCKINNEY ANTHONY A	Chief Operating Off ...	Buy	M	0.10	4,166	417	4,166	0 to 4.2 K
Dec 26 2007	OREX	Orexigen Therapeut ...	Turner Heather D	Vice President	Option Exercise	A	14.26	16,000	228,160	16,000
Dec 26 2007	OREX	Orexigen Therapeut ...	TOLLEFSON GARY D	President and CEO	Option Exercise	A	14.26	80,000	1,140,800	80,000
Dec 26 2007	OREX	Orexigen Therapeut ...	MCKINNEY ANTHONY A	Chief Operating Off ...	Option Exercise	A	14.26	45,000	641,700	45,000
Dec 26 2007	OREX	Orexigen Therapeut ...	LANDBLOOM RONALD P	VP, Medical and Reg ...	Option Exercise	A	14.26	20,000	285,200	20,000
Dec 26 2007	OREX	Orexigen Therapeut ...	LANCASTER JAMES C JR	VP of Commercial Op ...	Option Exercise	A	14.26	5,000	71,300	5,000
Dec 26 2007	OREX	Orexigen Therapeut ...	DUNAYEVICH EDUARDO	Chief Medical Offic ...	Option Exercise	A	14.26	47,000	670,220	47,000
Dec 26 2007	OREX	Orexigen Therapeut ...	COWLEY MICHAEL A	Chief Scientific Of ...	Option Exercise	A	14.26	10,000	142,600	10,000
Dec 26 2007	OREX	Orexigen Therapeut ...	COOPER GRAHAM K	CFO and Treasurer	Option Exercise	A	14.26	45,000	641,700	45,000
Dec 26 2007	OREX	Orexigen Therapeut ...	BYMASTER FRANKLIN P	VP of Neuroscience	Option Exercise	A	14.26	4,000	57,040	4,000
Dec 21 2007	OREX	Orexigen Therapeut ...	DUNAYEVICH EDUARDO	Chief Medical Offic ...	Option Exercise	M	2.00	5,000	10,000	240,000
Dec 21 2007	OREX	Orexigen Therapeut ...	DUNAYEVICH EDUARDO	Chief Medical Offic ...	Sell	S	14.15	556	7,867	0	556 to 0 (-100.00 %)
Dec 21 2007	OREX	Orexigen Therapeut ...	DUNAYEVICH EDUARDO	Chief Medical Offic ...	Sell	S	14.14	56	792	556	612 to 556 (-9.15 %)
Dec 21 2007	OREX	Orexigen Therapeut ...	DUNAYEVICH EDUARDO	Chief Medical Offic ...	Sell	S	14.13	111	1,568	612	723 to 612 (-15.35 %)
Dec 21 2007	OREX	Orexigen Therapeut ...	DUNAYEVICH EDUARDO	Chief Medical Offic ...	Sell	S	14.12	112	1,581	723	835 to 723 (-13.41 %)
Dec 21 2007	OREX	Orexigen Therapeut ...	DUNAYEVICH EDUARDO	Chief Medical Offic ...	Sell	S	14.11	83	1,171	835	918 to 835 (-9.04 %)
Dec 21 2007	OREX	Orexigen Therapeut ...	DUNAYEVICH EDUARDO	Chief Medical Offic ...	Sell	S	14.10	1,389	19,585	918	2.3 K to 918 (-60.21 %)
Dec 21 2007	OREX	Orexigen Therapeut ...	DUNAYEVICH EDUARDO	Chief Medical Offic ...	Sell	S	14.09	508	7,158	2,307	2.8 K to 2.3 K (-18.05 %)
Dec 21 2007	OREX	Orexigen Therapeut ...	DUNAYEVICH EDUARDO	Chief Medical Offic ...	Sell	S	14.08	556	7,828	2,815	3.4 K to 2.8 K (-16.49 %)
Dec 21 2007	OREX	Orexigen Therapeut ...	DUNAYEVICH EDUARDO	Chief Medical Offic ...	Sell	S	14.07	544	7,654	3,371	3.9 K to 3.4 K (-13.90 %)
Dec 21 2007	OREX	Orexigen Therapeut ...	DUNAYEVICH EDUARDO	Chief Medical Offic ...	Sell	S	14.06	529	7,438	3,915	4.4 K to 3.9 K (-11.90 %)
Dec 21 2007	OREX	Orexigen Therapeut ...	DUNAYEVICH EDUARDO	Chief Medical Offic ...	Sell	S	14.05	556	7,812	4,444	5 K to 4.4 K (-11.12 %)
Dec 21 2007	OREX	Orexigen Therapeut ...	DUNAYEVICH EDUARDO	Chief Medical Offic ...	Buy	M	2.00	5,000	10,000	5,000	0 to 5 K
Dec 21 2007	OREX	Orexigen Therapeut ...	COOPER GRAHAM K	CFO and Treasurer	Option Exercise	M	0.70	4,000	2,800	254,944
Dec 21 2007	OREX	Orexigen Therapeut ...	COOPER GRAHAM K	CFO and Treasurer	Sell	S	14.15	444	6,283	0	444 to 0 (-100.00 %)
Dec 21 2007	OREX	Orexigen Therapeut ...	COOPER GRAHAM K	CFO and Treasurer	Sell	S	14.14	44	622	444	488 to 444 (-9.02 %)
Dec 21 2007	OREX	Orexigen Therapeut ...	COOPER GRAHAM K	CFO and Treasurer	Sell	S	14.13	88	1,243	488	576 to 488 (-15.28 %)
Dec 21 2007	OREX	Orexigen Therapeut ...	COOPER GRAHAM K	CFO and Treasurer	Sell	S	14.12	90	1,271	576	666 to 576 (-13.51 %)
Dec 21 2007	OREX	Orexigen Therapeut ...	COOPER GRAHAM K	CFO and Treasurer	Sell	S	14.11	67	945	666	733 to 666 (-9.14 %)
Dec 21 2007	OREX	Orexigen Therapeut ...	COOPER GRAHAM K	CFO and Treasurer	Sell	S	14.10	1,110	15,651	733	1.8 K to 733 (-60.23 %)
Dec 21 2007	OREX	Orexigen Therapeut ...	COOPER GRAHAM K	CFO and Treasurer	Sell	S	14.09	412	5,805	1,843	2.3 K to 1.8 K (-18.27 %)
Dec 21 2007	OREX	Orexigen Therapeut ...	COOPER GRAHAM K	CFO and Treasurer	Sell	S	14.08	444	6,252	2,255	2.7 K to 2.3 K (-16.45 %)
Dec 21 2007	OREX	Orexigen Therapeut ...	COOPER GRAHAM K	CFO and Treasurer	Sell	S	14.07	436	6,135	2,699	3.1 K to 2.7 K (-13.91 %)
Dec 21 2007	OREX	Orexigen Therapeut ...	COOPER GRAHAM K	CFO and Treasurer	Sell	S	14.06	421	5,919	3,135	3.6 K to 3.1 K (-11.84 %)
Dec 21 2007	OREX	Orexigen Therapeut ...	COOPER GRAHAM K	CFO and Treasurer	Sell	S	14.05	444	6,238	3,556	4 K to 3.6 K (-11.10 %)
Dec 21 2007	OREX	Orexigen Therapeut ...	COOPER GRAHAM K	CFO and Treasurer	Buy	M	0.70	4,000	2,800	4,000	0 to 4 K
Dec 19 2007	OREX	Orexigen Therapeut ...	TOLLEFSON GARY D	President and CEO	Option Exercise	M	0.60	15,000	9,000	840,883
Dec 19 2007	OREX	Orexigen Therapeut ...	TOLLEFSON GARY D	President and CEO	Sell	S	14.35	1,000	14,350	0	1,000 to 0 (-100.00 %)
Dec 19 2007	OREX	Orexigen Therapeut ...	TOLLEFSON GARY D	President and CEO	Sell	S	14.34	1,000	14,340	1,000	2 K to 1,000 (-50.00 %)
Dec 19 2007	OREX	Orexigen Therapeut ...	TOLLEFSON GARY D	President and CEO	Sell	S	14.33	2,000	28,660	2,000	4 K to 2 K (-50.00 %)
Dec 19 2007	OREX	Orexigen Therapeut ...	TOLLEFSON GARY D	President and CEO	Sell	S	14.30	1,000	14,300	4,000	5 K to 4 K (-20.00 %)
Dec 19 2007	OREX	Orexigen Therapeut ...	TOLLEFSON GARY D	President and CEO	Sell	S	14.29	1,000	14,290	5,000	6 K to 5 K (-16.67 %)
Dec 19 2007	OREX	Orexigen Therapeut ...	TOLLEFSON GARY D	President and CEO	Sell	S	14.27	4,000	57,080	6,000	10 K to 6 K (-40.00 %)
Dec 19 2007	OREX	Orexigen Therapeut ...	TOLLEFSON GARY D	President and CEO	Sell	S	14.26	3,000	42,780	10,000	13 K to 10 K (-23.08 %)
Dec 19 2007	OREX	Orexigen Therapeut ...	TOLLEFSON GARY D	President and CEO	Sell	S	14.25	1,000	14,250	13,000	14 K to 13 K (-7.14 %)
Dec 19 2007	OREX	Orexigen Therapeut ...	TOLLEFSON GARY D	President and CEO	Sell	S	14.15	1,000	14,150	14,000	15 K to 14 K (-6.67 %)
Dec 19 2007	OREX	Orexigen Therapeut ...	TOLLEFSON GARY D	President and CEO	Buy	M	0.60	15,000	9,000	15,000	0 to 15 K
Dec 19 2007	OREX	Orexigen Therapeut ...	WEBER ECKARD	Director	Gift	G	0.00	810,000	0	810,000	0 to 810 K
Dec 19 2007	OREX	Orexigen Therapeut ...	WEBER ECKARD	Director	Gift	G	0.00	810,000	0	0	810 K to 0 (-100.00 %)
Nov 30 2007	OREX	Orexigen Therapeut ...	COWLEY MICHAEL A	Chief Scientific Of ...	Sell	S	14.40	4,156	59,846	181,344	185.5 K to 181.3 K (-2.24 %)
Nov 30 2007	OREX	Orexigen Therapeut ...	COWLEY MICHAEL A	Chief Scientific Of ...	Sell	S	14.35	7,500	107,625	185,500	193 K to 185.5 K (-3.89 %)
Nov 30 2007	OREX	Orexigen Therapeut ...	COWLEY MICHAEL A	Chief Scientific Of ...	Sell	S	14.30	5,000	71,500	193,000	198 K to 193 K (-2.53 %)
Nov 30 2007	OREX	Orexigen Therapeut ...	COWLEY MICHAEL A	Chief Scientific Of ...	Sell	S	14.25	10,000	142,500	198,000	208 K to 198 K (-4.81 %)
Nov 30 2007	OREX	Orexigen Therapeut ...	COWLEY MICHAEL A	Chief Scientific Of ...	Sell	S	14.20	7,500	106,500	208,000	215.5 K to 208 K (-3.48 %)
Nov 30 2007	OREX	Orexigen Therapeut ...	COWLEY MICHAEL A	Chief Scientific Of ...	Sell	S	14.15	1,000	14,150	215,500	216.5 K to 215.5 K (-0.46 %)
Nov 29 2007	OREX	Orexigen Therapeut ...	DOMAIN PARTNERS V LP	10% Owner	Sell	J	0.00	900,000	0	3,543,832	4.4 M to 3.5 M (-20.25 %)
Nov 29 2007	OREX	Orexigen Therapeut ...	MORE ROBERT J	10% Owner	Sell	S	14.27	21,000	299,670	83,975	105 K to 84 K (-20.00 %)
Nov 29 2007	OREX	Orexigen Therapeut ...	MORE ROBERT J	10% Owner	Buy	J	0.00	16,606	0	16,606	0 to 16.6 K
Nov 29 2007	OREX	Orexigen Therapeut ...	MORE ROBERT J	10% Owner	Buy	J	0.00	1,963	0	1,963	0 to 2 K
Nov 29 2007	OREX	Orexigen Therapeut ...	MORE ROBERT J	10% Owner	Sell	J	0.00	900,000	0	3,543,832	4.4 M to 3.5 M (-20.25 %)
Nov 29 2007	OREX	Orexigen Therapeut ...	DP V ASSOCIATES LP	10% Owner	Sell	S	14.27	21,000	299,670	83,975	105 K to 84 K (-20.00 %)
Nov 29 2007	OREX	Orexigen Therapeut ...	BLAIR JAMES C	10% Owner	Sell	S	14.27	21,000	299,670	83,975	105 K to 84 K (-20.00 %)
Nov 29 2007	OREX	Orexigen Therapeut ...	BLAIR JAMES C	10% Owner	Buy	J	0.00	19,373	0	19,373	0 to 19.4 K
Nov 29 2007	OREX	Orexigen Therapeut ...	BLAIR JAMES C	10% Owner	Buy	J	0.00	1,963	0	1,963	0 to 2 K
Nov 29 2007	OREX	Orexigen Therapeut ...	BLAIR JAMES C	10% Owner	Sell	J	0.00	900,000	0	3,543,832	4.4 M to 3.5 M (-20.25 %)
Nov 29 2007	OREX	Orexigen Therapeut ...	SCHOEMAKER KATHLEEN K	10% Owner	Sell	S	14.27	21,000	299,670	83,975	105 K to 84 K (-20.00 %)
Nov 29 2007	OREX	Orexigen Therapeut ...	SCHOEMAKER KATHLEEN K	10% Owner	Buy	J	0.00	9,058	0	9,058	0 to 9.1 K
Nov 29 2007	OREX	Orexigen Therapeut ...	SCHOEMAKER KATHLEEN K	10% Owner	Buy	J	0.00	1,963	0	1,963	0 to 2 K
Nov 29 2007	OREX	Orexigen Therapeut ...	SCHOEMAKER KATHLEEN K	10% Owner	Sell	J	0.00	900,000	0	3,543,832	4.4 M to 3.5 M (-20.25 %)
Nov 29 2007	OREX	Orexigen Therapeut ...	TREU JESSE I	10% Owner	Buy	J	0.00	14,090	0	14,090	0 to 14.1 K
Nov 29 2007	OREX	Orexigen Therapeut ...	TREU JESSE I	10% Owner	Sell	S	14.27	21,000	299,670	83,975	105 K to 84 K (-20.00 %)
Nov 29 2007	OREX	Orexigen Therapeut ...	TREU JESSE I	10% Owner	Buy	J	0.00	15,096	0	15,096	0 to 15.1 K
Nov 29 2007	OREX	Orexigen Therapeut ...	TREU JESSE I	10% Owner	Buy	J	0.00	1,963	0	1,963	0 to 2 K
Nov 29 2007	OREX	Orexigen Therapeut ...	TREU JESSE I	10% Owner	Sell	J	0.00	900,000	0	3,543,832	4.4 M to 3.5 M (-20.25 %)
Nov 29 2007	OREX	Orexigen Therapeut ...	DOVEY BRIAN H	Director	Sell	S	14.27	21,000	299,670	83,975	105 K to 84 K (-20.00 %)
Nov 29 2007	OREX	Orexigen Therapeut ...	DOVEY BRIAN H	Director	Buy	J	0.00	20,128	0	20,128	0 to 20.1 K
Nov 29 2007	OREX	Orexigen Therapeut ...	DOVEY BRIAN H	Director	Buy	J	0.00	1,963	0	1,963	0 to 2 K
Nov 29 2007	OREX	Orexigen Therapeut ...	DOVEY BRIAN H	Director	Sell	J	0.00	900,000	0	3,543,832	4.4 M to 3.5 M (-20.25 %)
Nov 28 2007	OREX	Orexigen Therapeut ...	LANDBLOOM RONALD P	VP, Medical and Reg ...	Option Exercise	M	2.00	5,000	10,000	245,000
Nov 28 2007	OREX	Orexigen Therapeut ...	LANDBLOOM RONALD P	VP, Medical and Reg ...	Sell	S	14.56	123	1,791	0	123 to 0 (-100.00 %)
Nov 28 2007	OREX	Orexigen Therapeut ...	LANDBLOOM RONALD P	VP, Medical and Reg ...	Sell	S	14.55	82	1,193	123	205 to 123 (-40.00 %)
Nov 28 2007	OREX	Orexigen Therapeut ...	LANDBLOOM RONALD P	VP, Medical and Reg ...	Sell	S	14.47	41	593	205	246 to 205 (-16.67 %)
Nov 28 2007	OREX	Orexigen Therapeut ...	LANDBLOOM RONALD P	VP, Medical and Reg ...	Sell	S	14.45	369	5,332	246	615 to 246 (-60.00 %)

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