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General | Insiders | Insider Transactions | Monthly Overview | Weekly Overview

Overview of all insider trading transactions in Regulus Therapeutics Inc.. Get notifications about new insider transactions in Regulus Therapeutics Inc. for free.

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Date	Ticker	Company	Owner	Relationship	Transaction	Code	Cost ($)	Shares	Transaction Value ($)	Total Shares	% Holdings
Jun 02 2017	RGLS	Regulus Therapeuti ...	FOLETTA MARK G	Director	Option Exercise	A	1.45	30,000	43,500	30,000
Jun 02 2017	RGLS	Regulus Therapeuti ...	BALTIMORE DAVID	Director	Option Exercise	A	1.45	30,000	43,500	30,000
Jun 02 2017	RGLS	Regulus Therapeuti ...	Witz Pascale	Director	Option Exercise	A	1.45	60,000	87,000	60,000
May 12 2017	RGLS	Regulus Therapeuti ...	Chevallard Daniel R.	Chief Financial Off ...	Option Exercise	A	1.65	100,000	165,000	100,000
May 08 2017	RGLS	Regulus Therapeuti ...	Hagan Joseph P	President and CEO	Option Exercise	A	1.70	750,000	1,275,000	750,000
May 08 2017	RGLS	Regulus Therapeuti ...	WRIGHT TIMOTHY MICHAEL	Chief R & D Officer	Option Exercise	A	1.70	350,000	595,000	350,000
Mar 23 2017	RGLS	Regulus Therapeuti ...	PAPADOPOULOS STELIOS	Director	Buy	P	1.23	300,000	368,100	700,677	400.7 K to 700.7 K (+74.87 %)
Mar 23 2017	RGLS	Regulus Therapeuti ...	PAPADOPOULOS STELIOS	Director	Buy	P	1.20	200,000	239,800	400,677	200.7 K to 400.7 K (+99.66 %)
Mar 07 2017	RGLS	Regulus Therapeuti ...	RASTETTER WILLIAM H	Director	Buy	P	1.15	250,000	287,500	350,000	100 K to 350 K (+250.00 %)
Feb 23 2017	RGLS	Regulus Therapeuti ...	WRIGHT TIMOTHY MICHAEL	Chief R & D Officer	Option Exercise	A	1.20	32,412	38,894	32,412
Feb 23 2017	RGLS	Regulus Therapeuti ...	Hagan Joseph P	Chief Operating Off ...	Option Exercise	A	1.20	160,000	192,000	160,000
Feb 23 2017	RGLS	Regulus Therapeuti ...	GRINT PAUL C	President & CEO	Option Exercise	A	1.20	410,000	492,000	410,000
Feb 01 2017	RGLS	Regulus Therapeuti ...	Hagan Joseph P	Chief Operating Off ...	Option Exercise	A	5.77	30,000	173,100	30,000
Feb 01 2017	RGLS	Regulus Therapeuti ...	GRINT PAUL C	President & CEO	Option Exercise	A	6.35	130,000	825,500	130,000
Oct 07 2016	RGLS	Regulus Therapeuti ...	Hagan Joseph P	Chief Operating Off ...	Option Exercise	A	3.52	59,625	209,880	59,625
Oct 07 2016	RGLS	Regulus Therapeuti ...	GRINT PAUL C	President & CEO	Option Exercise	A	3.52	186,640	656,973	186,640
Oct 05 2016	RGLS	Regulus Therapeuti ...	WRIGHT TIMOTHY MICHAEL	Chief R & D Officer	Option Exercise	A	3.30	450,000	1,485,000	450,000
Jun 03 2016	RGLS	Regulus Therapeuti ...	WILLIAMS DOUGLAS E	Director	Option Exercise	A	6.20	36,620	227,044	36,620
Jun 03 2016	RGLS	Regulus Therapeuti ...	RASTETTER WILLIAM H	Director	Option Exercise	A	6.20	36,620	227,044	36,620
Jun 03 2016	RGLS	Regulus Therapeuti ...	PAPADOPOULOS STELIOS	Director	Option Exercise	A	6.20	36,620	227,044	36,620
Jun 03 2016	RGLS	Regulus Therapeuti ...	FOLETTA MARK G	Director	Option Exercise	A	6.20	36,620	227,044	36,620
Jun 03 2016	RGLS	Regulus Therapeuti ...	BALTIMORE DAVID	Director	Option Exercise	A	6.20	36,620	227,044	36,620
Jun 03 2016	RGLS	Regulus Therapeuti ...	Rosen Hugh	Director	Option Exercise	A	6.20	70,952	439,902	70,952
Mar 07 2016	RGLS	Regulus Therapeuti ...	Hagan Joseph P	Chief Operating Off ...	Buy	P	7.19	10,000	71,900	10,000	0 to 10 K
Feb 24 2016	RGLS	Regulus Therapeuti ...	ALNYLAM PHARMACEUTICALS, INC.	10% Owner	Sell	S	7.18	1,000,000	7,180,000	4,896,716	5.9 M to 4.9 M (-16.96 %)
Feb 05 2016	RGLS	Regulus Therapeuti ...	GRINT PAUL C	President & CEO	Option Exercise	A	6.35	265,000	1,682,750	265,000
Jan 06 2016	RGLS	Regulus Therapeuti ...	GRINT PAUL C	President & CEO	Option Exercise	A	7.58	30,000	227,400	30,000
Jan 06 2016	RGLS	Regulus Therapeuti ...	Hagan Joseph P	Chief Operating Off ...	Option Exercise	A	8.57	420,000	3,599,400	420,000
Aug 13 2015	RGLS	Regulus Therapeuti ...	FOLETTA MARK G	Director	Buy	P	7.64	10,000	76,405	10,000	0 to 10 K
Aug 07 2015	RGLS	Regulus Therapeuti ...	PAPADOPOULOS STELIOS	Director	Option Exercise	M	2.66	15,677	41,701	1,823
Aug 07 2015	RGLS	Regulus Therapeuti ...	PAPADOPOULOS STELIOS	Director	Option Exercise	M	1.74	17,500	30,450	0
Aug 07 2015	RGLS	Regulus Therapeuti ...	PAPADOPOULOS STELIOS	Director	Option Exercise	M	0.38	17,500	6,650	0
Aug 07 2015	RGLS	Regulus Therapeuti ...	PAPADOPOULOS STELIOS	Director	Buy	M	2.66	15,677	41,701	200,677	185 K to 200.7 K (+8.47 %)
Aug 07 2015	RGLS	Regulus Therapeuti ...	PAPADOPOULOS STELIOS	Director	Buy	M	1.74	17,500	30,450	185,000	167.5 K to 185 K (+10.45 %)
Aug 07 2015	RGLS	Regulus Therapeuti ...	PAPADOPOULOS STELIOS	Director	Buy	M	0.38	17,500	6,650	167,500	150 K to 167.5 K (+11.67 %)
Jul 21 2015	RGLS	Regulus Therapeuti ...	RASTETTER WILLIAM H	Director	Buy	P	10.19	61,235	624,199	100,000	38.8 K to 100 K (+157.96 %)
Jul 21 2015	RGLS	Regulus Therapeuti ...	RASTETTER WILLIAM H	Director	Buy	P	10.13	38,765	392,779	38,765	0 to 38.8 K
Jul 17 2015	RGLS	Regulus Therapeuti ...	ISIS PHARMACEUTICALS INC	10% Owner	Sell	S	10.21	111,000	1,133,754	5,173,172	5.3 M to 5.2 M (-2.10 %)
Jul 17 2015	RGLS	Regulus Therapeuti ...	ISIS PHARMACEUTICALS INC	10% Owner	Sell	S	10.79	167,000	1,801,362	5,284,172	5.5 M to 5.3 M (-3.06 %)
Jul 17 2015	RGLS	Regulus Therapeuti ...	ISIS PHARMACEUTICALS INC	10% Owner	Sell	S	10.76	65,133	700,961	5,451,172	5.5 M to 5.5 M (-1.18 %)
Jul 02 2015	RGLS	Regulus Therapeuti ...	ISIS PHARMACEUTICALS INC	10% Owner	Sell	S	10.79	13,248	143,010	5,516,305	5.5 M to 5.5 M (-0.24 %)
Jul 02 2015	RGLS	Regulus Therapeuti ...	ISIS PHARMACEUTICALS INC	10% Owner	Gift	G	0.00	13,248	0	5,529,553	5.5 M to 5.5 M (+0.24 %)
Jun 26 2015	RGLS	Regulus Therapeuti ...	GRINT PAUL C	President & CEO	Option Exercise	A	10.22	500,000	5,110,000	500,000
Jun 26 2015	RGLS	Regulus Therapeuti ...	PAPADOPOULOS STELIOS	Director	Option Exercise	A	10.02	17,500	175,350	17,500
Jun 26 2015	RGLS	Regulus Therapeuti ...	FOLETTA MARK G	Director	Option Exercise	A	10.02	17,500	175,350	17,500
Jun 26 2015	RGLS	Regulus Therapeuti ...	RASTETTER WILLIAM H	Director	Option Exercise	A	10.02	17,500	175,350	17,500
Jun 26 2015	RGLS	Regulus Therapeuti ...	CARTER BRUCE L A	Director	Option Exercise	A	10.02	17,500	175,350	17,500
Jun 26 2015	RGLS	Regulus Therapeuti ...	BALTIMORE DAVID	Director	Option Exercise	A	10.02	17,500	175,350	17,500
Jun 26 2015	RGLS	Regulus Therapeuti ...	CARTER BRUCE L A	Director	Option Exercise	A	10.02	17,500	175,350	17,500
Jun 26 2015	RGLS	Regulus Therapeuti ...	WILLIAMS DOUGLAS E	Director	Option Exercise	A	10.02	17,500	175,350	17,500
Apr 21 2015	RGLS	Regulus Therapeuti ...	XANTHOPOULOS KLEANTHIS G	President and CEO	Option Exercise	M	0.38	60,000	22,800	8,287
Apr 21 2015	RGLS	Regulus Therapeuti ...	XANTHOPOULOS KLEANTHIS G	President and CEO	Option Exercise	M	0.38	66,071	25,107	68,287
Apr 21 2015	RGLS	Regulus Therapeuti ...	XANTHOPOULOS KLEANTHIS G	President and CEO	Option Exercise	M	0.38	73,929	28,093	134,358
Apr 21 2015	RGLS	Regulus Therapeuti ...	XANTHOPOULOS KLEANTHIS G	President and CEO	Sell	S	17.73	60,000	1,063,980	3,705	63.7 K to 3.7 K (-94.18 %)
Apr 21 2015	RGLS	Regulus Therapeuti ...	XANTHOPOULOS KLEANTHIS G	President and CEO	Buy	M	0.38	60,000	22,800	63,705	3.7 K to 63.7 K (+1,619.43 %)
Apr 21 2015	RGLS	Regulus Therapeuti ...	XANTHOPOULOS KLEANTHIS G	President and CEO	Sell	S	16.85	66,071	1,113,514	3,705	69.8 K to 3.7 K (-94.69 %)
Apr 21 2015	RGLS	Regulus Therapeuti ...	XANTHOPOULOS KLEANTHIS G	President and CEO	Buy	M	0.38	66,071	25,107	69,776	3.7 K to 69.8 K (+1,783.29 %)
Apr 21 2015	RGLS	Regulus Therapeuti ...	XANTHOPOULOS KLEANTHIS G	President and CEO	Sell	S	16.94	73,929	1,252,002	3,705	77.6 K to 3.7 K (-95.23 %)
Apr 21 2015	RGLS	Regulus Therapeuti ...	XANTHOPOULOS KLEANTHIS G	President and CEO	Buy	M	0.38	73,929	28,093	77,634	3.7 K to 77.6 K (+1,995.38 %)
Apr 14 2015	RGLS	Regulus Therapeuti ...	CARTER BRUCE L A	Director	Option Exercise	M	4.78	20,000	95,600	10,000
Apr 14 2015	RGLS	Regulus Therapeuti ...	CARTER BRUCE L A	Director	Sell	S	17.66	20,000	353,164	0	20 K to 0 (-100.00 %)
Apr 14 2015	RGLS	Regulus Therapeuti ...	CARTER BRUCE L A	Director	Buy	M	4.78	20,000	95,600	20,000	0 to 20 K
Mar 05 2015	RGLS	Regulus Therapeuti ...	XANTHOPOULOS KLEANTHIS G	President and CEO	Option Exercise	M	0.38	89,230	33,907	208,287
Mar 05 2015	RGLS	Regulus Therapeuti ...	XANTHOPOULOS KLEANTHIS G	President and CEO	Sell	S	20.81	23,616	491,551	2,466	26.1 K to 2.5 K (-90.55 %)
Mar 05 2015	RGLS	Regulus Therapeuti ...	XANTHOPOULOS KLEANTHIS G	President and CEO	Sell	S	20.06	65,614	1,316,512	26,082	91.7 K to 26.1 K (-71.56 %)
Mar 05 2015	RGLS	Regulus Therapeuti ...	XANTHOPOULOS KLEANTHIS G	President and CEO	Buy	M	0.38	89,230	33,907	91,696	2.5 K to 91.7 K (+3,618.41 %)
Mar 03 2015	RGLS	Regulus Therapeuti ...	XANTHOPOULOS KLEANTHIS G	President and CEO	Option Exercise	M	0.38	70	27	297,517
Mar 03 2015	RGLS	Regulus Therapeuti ...	XANTHOPOULOS KLEANTHIS G	President and CEO	Sell	S	19.50	70	1,365	2,466	2.5 K to 2.5 K (-2.76 %)
Mar 03 2015	RGLS	Regulus Therapeuti ...	XANTHOPOULOS KLEANTHIS G	President and CEO	Buy	M	0.38	70	27	2,536	2.5 K to 2.5 K (+2.84 %)
Feb 03 2015	RGLS	Regulus Therapeuti ...	XANTHOPOULOS KLEANTHIS G	President and CEO	Option Exercise	M	0.38	2,400	912	297,587
Feb 03 2015	RGLS	Regulus Therapeuti ...	XANTHOPOULOS KLEANTHIS G	President and CEO	Option Exercise	M	0.38	3,300	1,254	299,987
Feb 03 2015	RGLS	Regulus Therapeuti ...	XANTHOPOULOS KLEANTHIS G	President and CEO	Sell	S	19.77	2,400	47,440	2,466	4.9 K to 2.5 K (-49.32 %)
Feb 03 2015	RGLS	Regulus Therapeuti ...	XANTHOPOULOS KLEANTHIS G	President and CEO	Buy	M	0.38	2,400	912	4,866	2.5 K to 4.9 K (+97.32 %)
Feb 03 2015	RGLS	Regulus Therapeuti ...	XANTHOPOULOS KLEANTHIS G	President and CEO	Sell	S	19.50	3,300	64,351	2,466	5.8 K to 2.5 K (-57.23 %)
Feb 03 2015	RGLS	Regulus Therapeuti ...	XANTHOPOULOS KLEANTHIS G	President and CEO	Buy	M	0.38	3,300	1,254	5,766	2.5 K to 5.8 K (+133.82 %)
Jan 30 2015	RGLS	Regulus Therapeuti ...	Gibson Neil W	Chief Scientific Of ...	Sell	S	18.66	8,655	161,493	0	8.7 K to 0 (-100.00 %)
Jan 30 2015	RGLS	Regulus Therapeuti ...	Gibson Neil W	Chief Scientific Of ...	Sell	S	17.98	71,345	1,282,812	8,655	80 K to 8.7 K (-89.18 %)
Jan 30 2015	RGLS	Regulus Therapeuti ...	XANTHOPOULOS KLEANTHIS G	President and CEO	Option Exercise	M	0.38	60,000	22,800	303,287
Jan 30 2015	RGLS	Regulus Therapeuti ...	XANTHOPOULOS KLEANTHIS G	President and CEO	Option Exercise	M	0.38	85,000	32,300	363,287
Jan 30 2015	RGLS	Regulus Therapeuti ...	XANTHOPOULOS KLEANTHIS G	President and CEO	Sell	S	18.40	26,227	482,627	2,466	28.7 K to 2.5 K (-91.41 %)
Jan 30 2015	RGLS	Regulus Therapeuti ...	XANTHOPOULOS KLEANTHIS G	President and CEO	Sell	S	17.77	33,773	600,008	28,693	62.5 K to 28.7 K (-54.07 %)
Jan 30 2015	RGLS	Regulus Therapeuti ...	XANTHOPOULOS KLEANTHIS G	President and CEO	Buy	M	0.38	60,000	22,800	62,466	2.5 K to 62.5 K (+2,433.09 %)
Jan 30 2015	RGLS	Regulus Therapeuti ...	XANTHOPOULOS KLEANTHIS G	President and CEO	Sell	S	18.69	12,989	242,701	2,466	15.5 K to 2.5 K (-84.04 %)
Jan 30 2015	RGLS	Regulus Therapeuti ...	XANTHOPOULOS KLEANTHIS G	President and CEO	Sell	S	17.97	72,011	1,293,814	15,455	87.5 K to 15.5 K (-82.33 %)
Jan 30 2015	RGLS	Regulus Therapeuti ...	XANTHOPOULOS KLEANTHIS G	President and CEO	Buy	M	0.38	85,000	32,300	87,466	2.5 K to 87.5 K (+3,446.88 %)
Dec 15 2014	RGLS	Regulus Therapeuti ...	PAPADOPOULOS STELIOS	Director	Option Exercise	M	0.38	150,000	57,000	0
Dec 15 2014	RGLS	Regulus Therapeuti ...	PAPADOPOULOS STELIOS	Director	Buy	M	0.38	150,000	57,000	150,000	0 to 150 K
Dec 04 2014	RGLS	Regulus Therapeuti ...	XANTHOPOULOS KLEANTHIS G	President and CEO	Option Exercise	A	17.76	231,634	4,113,820	231,634
Dec 04 2014	RGLS	Regulus Therapeuti ...	Szekeres David Leslie	Chief Business Offi ...	Option Exercise	A	17.76	81,101	1,440,354	81,101
Dec 04 2014	RGLS	Regulus Therapeuti ...	GRINT PAUL C	Chief Medical Offic ...	Option Exercise	A	17.76	50,870	903,451	50,870
Dec 04 2014	RGLS	Regulus Therapeuti ...	Gibson Neil W	Chief Scientific Of ...	Option Exercise	A	17.76	90,378	1,605,113	90,378
Dec 01 2014	RGLS	Regulus Therapeuti ...	Gibson Neil W	Chief Scientific Of ...	Option Exercise	M	1.74	2,500	4,350	111,500
Dec 01 2014	RGLS	Regulus Therapeuti ...	Gibson Neil W	Chief Scientific Of ...	Sell	S	19.63	1,500	29,445	80,000	81.5 K to 80 K (-1.84 %)
Dec 01 2014	RGLS	Regulus Therapeuti ...	Gibson Neil W	Chief Scientific Of ...	Sell	S	18.80	1,000	18,800	81,500	82.5 K to 81.5 K (-1.21 %)
Dec 01 2014	RGLS	Regulus Therapeuti ...	Gibson Neil W	Chief Scientific Of ...	Buy	M	1.74	2,500	4,350	82,500	80 K to 82.5 K (+3.13 %)
Nov 14 2014	RGLS	Regulus Therapeuti ...	ASTRAZENECA PLC	10% Owner	Sell	S	17.00	2,000,000	34,000,000	4,250,000	6.3 M to 4.3 M (-32.00 %)
Nov 05 2014	RGLS	Regulus Therapeuti ...	ISIS PHARMACEUTICALS INC	10% Owner	Sell	S	15.94	1,279,411	20,390,613	5,516,305	6.8 M to 5.5 M (-18.83 %)
Oct 31 2014	RGLS	Regulus Therapeuti ...	XANTHOPOULOS KLEANTHIS G	President and CEO	Option Exercise	M	0.38	3,505	1,332	448,287
Oct 31 2014	RGLS	Regulus Therapeuti ...	XANTHOPOULOS KLEANTHIS G	President and CEO	Sell	S	20.41	100	2,041	2,466	2.6 K to 2.5 K (-3.90 %)
Oct 31 2014	RGLS	Regulus Therapeuti ...	XANTHOPOULOS KLEANTHIS G	President and CEO	Sell	S	19.78	2,005	39,659	2,566	4.6 K to 2.6 K (-43.86 %)
Oct 31 2014	RGLS	Regulus Therapeuti ...	XANTHOPOULOS KLEANTHIS G	President and CEO	Sell	S	18.66	1,400	26,124	4,571	6 K to 4.6 K (-23.45 %)
Oct 31 2014	RGLS	Regulus Therapeuti ...	XANTHOPOULOS KLEANTHIS G	President and CEO	Buy	M	0.38	3,505	1,332	5,971	2.5 K to 6 K (+142.13 %)
Oct 31 2014	RGLS	Regulus Therapeuti ...	Gibson Neil W	Chief Scientific Of ...	Option Exercise	M	1.74	2,500	4,350	114,000
Oct 31 2014	RGLS	Regulus Therapeuti ...	Gibson Neil W	Chief Scientific Of ...	Sell	S	20.41	200	4,082	80,000	80.2 K to 80 K (-0.25 %)
Oct 31 2014	RGLS	Regulus Therapeuti ...	Gibson Neil W	Chief Scientific Of ...	Sell	S	19.67	1,200	23,604	80,200	81.4 K to 80.2 K (-1.47 %)
Oct 31 2014	RGLS	Regulus Therapeuti ...	Gibson Neil W	Chief Scientific Of ...	Sell	S	18.68	1,100	20,548	81,400	82.5 K to 81.4 K (-1.33 %)
Oct 31 2014	RGLS	Regulus Therapeuti ...	Gibson Neil W	Chief Scientific Of ...	Buy	M	1.74	2,500	4,350	82,500	80 K to 82.5 K (+3.13 %)
Oct 24 2014	RGLS	Regulus Therapeuti ...	ISIS PHARMACEUTICALS INC	Director	Sell	S	15.19	1,850	28,109	6,795,716	6.8 M to 6.8 M (-0.03 %)
Oct 24 2014	RGLS	Regulus Therapeuti ...	ISIS PHARMACEUTICALS INC	Director	Sell	S	14.24	1,700	24,202	6,797,566	6.8 M to 6.8 M (-0.03 %)
Oct 24 2014	RGLS	Regulus Therapeuti ...	ISIS PHARMACEUTICALS INC	Director	Sell	S	14.00	109,534	1,533,125	6,799,266	6.9 M to 6.8 M (-1.59 %)
Oct 24 2014	RGLS	Regulus Therapeuti ...	ALNYLAM PHARMACEUTICALS, INC.	10% Owner	Sell	S	15.19	1,850	28,109	5,896,716	5.9 M to 5.9 M (-0.03 %)
Oct 24 2014	RGLS	Regulus Therapeuti ...	ALNYLAM PHARMACEUTICALS, INC.	10% Owner	Sell	S	14.24	1,700	24,202	5,898,566	5.9 M to 5.9 M (-0.03 %)
Oct 24 2014	RGLS	Regulus Therapeuti ...	ALNYLAM PHARMACEUTICALS, INC.	10% Owner	Sell	S	14.00	109,534	1,533,125	5,900,266	6 M to 5.9 M (-1.82 %)
Oct 22 2014	RGLS	Regulus Therapeuti ...	Szekeres David Leslie	CBO and General Cou ...	Option Exercise	A	8.51	40,000	340,400	40,000
Oct 22 2014	RGLS	Regulus Therapeuti ...	Gibson Neil W	Chief Scientific Of ...	Option Exercise	A	6.13	40,000	245,200	40,000
Oct 24 2014	RGLS	Regulus Therapeuti ...	Gibson Neil W	Chief Scientific Of ...	Option Exercise	M	1.74	3,300	5,742	116,500
Oct 24 2014	RGLS	Regulus Therapeuti ...	Gibson Neil W	Chief Scientific Of ...	Sell	S	14.44	3,300	47,644	80,000	83.3 K to 80 K (-3.96 %)
Oct 24 2014	RGLS	Regulus Therapeuti ...	Gibson Neil W	Chief Scientific Of ...	Buy	M	1.74	3,300	5,742	83,300	80 K to 83.3 K (+4.13 %)
Oct 22 2014	RGLS	Regulus Therapeuti ...	GRINT PAUL C	Chief Medical Offic ...	Option Exercise	A	7.58	40,000	303,200	40,000
Oct 22 2014	RGLS	Regulus Therapeuti ...	XANTHOPOULOS KLEANTHIS G	President and CEO	Option Exercise	A	6.13	88,000	539,440	88,000
Oct 21 2014	RGLS	Regulus Therapeuti ...	XANTHOPOULOS KLEANTHIS G	President and CEO	Option Exercise	M	0.38	300	114	451,792
Oct 21 2014	RGLS	Regulus Therapeuti ...	XANTHOPOULOS KLEANTHIS G	President and CEO	Option Exercise	M	0.38	400	152	452,092
Oct 21 2014	RGLS	Regulus Therapeuti ...	XANTHOPOULOS KLEANTHIS G	President and CEO	Sell	S	7.00	300	2,100	2,466	2.8 K to 2.5 K (-10.85 %)
Oct 21 2014	RGLS	Regulus Therapeuti ...	XANTHOPOULOS KLEANTHIS G	President and CEO	Buy	M	0.38	300	114	2,766	2.5 K to 2.8 K (+12.17 %)
Oct 21 2014	RGLS	Regulus Therapeuti ...	XANTHOPOULOS KLEANTHIS G	President and CEO	Sell	S	7.04	400	2,816	2,466	2.9 K to 2.5 K (-13.96 %)
Oct 21 2014	RGLS	Regulus Therapeuti ...	XANTHOPOULOS KLEANTHIS G	President and CEO	Buy	M	0.38	400	152	2,866	2.5 K to 2.9 K (+16.22 %)
Oct 17 2014	RGLS	Regulus Therapeuti ...	ISIS PHARMACEUTICALS INC	Director	Sell	S	6.79	3,000	20,371	6,908,800	6.9 M to 6.9 M (-0.04 %)
Oct 17 2014	RGLS	Regulus Therapeuti ...	ISIS PHARMACEUTICALS INC	Director	Sell	S	6.76	4,800	32,450	6,911,800	6.9 M to 6.9 M (-0.07 %)
Oct 17 2014	RGLS	Regulus Therapeuti ...	ISIS PHARMACEUTICALS INC	Director	Sell	S	6.67	4,300	28,687	6,916,600	6.9 M to 6.9 M (-0.06 %)
Oct 17 2014	RGLS	Regulus Therapeuti ...	ALNYLAM PHARMACEUTICALS, INC.	10% Owner	Sell	S	6.79	3,000	20,371	6,009,800	6 M to 6 M (-0.05 %)
Oct 17 2014	RGLS	Regulus Therapeuti ...	ALNYLAM PHARMACEUTICALS, INC.	10% Owner	Sell	S	6.76	4,800	32,450	6,012,800	6 M to 6 M (-0.08 %)
Oct 17 2014	RGLS	Regulus Therapeuti ...	ALNYLAM PHARMACEUTICALS, INC.	10% Owner	Sell	S	6.67	4,300	28,687	6,017,600	6 M to 6 M (-0.07 %)
Oct 14 2014	RGLS	Regulus Therapeuti ...	XANTHOPOULOS KLEANTHIS G	President and CEO	Option Exercise	M	0.38	400	152	452,492
Oct 14 2014	RGLS	Regulus Therapeuti ...	XANTHOPOULOS KLEANTHIS G	President and CEO	Option Exercise	M	0.38	105	40	452,892
Oct 14 2014	RGLS	Regulus Therapeuti ...	XANTHOPOULOS KLEANTHIS G	President and CEO	Sell	S	7.00	400	2,800	2,466	2.9 K to 2.5 K (-13.96 %)
Oct 14 2014	RGLS	Regulus Therapeuti ...	XANTHOPOULOS KLEANTHIS G	President and CEO	Buy	M	0.38	400	152	2,866	2.5 K to 2.9 K (+16.22 %)
Oct 14 2014	RGLS	Regulus Therapeuti ...	XANTHOPOULOS KLEANTHIS G	President and CEO	Sell	S	7.00	105	735	2,466	2.6 K to 2.5 K (-4.08 %)
Oct 14 2014	RGLS	Regulus Therapeuti ...	XANTHOPOULOS KLEANTHIS G	President and CEO	Buy	M	0.38	105	40	2,571	2.5 K to 2.6 K (+4.26 %)
Oct 10 2014	RGLS	Regulus Therapeuti ...	ISIS PHARMACEUTICALS INC	Director	Sell	S	6.41	2,000	12,813	6,920,900	6.9 M to 6.9 M (-0.03 %)
Oct 10 2014	RGLS	Regulus Therapeuti ...	ISIS PHARMACEUTICALS INC	Director	Sell	S	6.58	4,750	31,238	6,922,900	6.9 M to 6.9 M (-0.07 %)
Oct 10 2014	RGLS	Regulus Therapeuti ...	ISIS PHARMACEUTICALS INC	Director	Sell	S	6.63	3,300	21,888	6,927,650	6.9 M to 6.9 M (-0.05 %)
Oct 10 2014	RGLS	Regulus Therapeuti ...	ALNYLAM PHARMACEUTICALS, INC.	10% Owner	Sell	S	6.41	2,000	12,813	6,021,900	6 M to 6 M (-0.03 %)
Oct 10 2014	RGLS	Regulus Therapeuti ...	ALNYLAM PHARMACEUTICALS, INC.	10% Owner	Sell	S	6.58	4,750	31,238	6,023,900	6 M to 6 M (-0.08 %)
Oct 10 2014	RGLS	Regulus Therapeuti ...	ALNYLAM PHARMACEUTICALS, INC.	10% Owner	Sell	S	6.63	3,300	21,888	6,028,650	6 M to 6 M (-0.05 %)
Oct 03 2014	RGLS	Regulus Therapeuti ...	ISIS PHARMACEUTICALS INC	Director	Sell	S	6.88	3,300	22,688	6,930,950	6.9 M to 6.9 M (-0.05 %)
Oct 03 2014	RGLS	Regulus Therapeuti ...	ISIS PHARMACEUTICALS INC	Director	Sell	S	6.64	3,750	24,903	6,934,250	6.9 M to 6.9 M (-0.05 %)
Oct 03 2014	RGLS	Regulus Therapeuti ...	ISIS PHARMACEUTICALS INC	Director	Sell	S	6.71	3,250	21,808	6,938,000	6.9 M to 6.9 M (-0.05 %)
Oct 03 2014	RGLS	Regulus Therapeuti ...	ALNYLAM PHARMACEUTICALS, INC.	10% Owner	Sell	S	6.88	3,300	22,688	6,031,950	6 M to 6 M (-0.05 %)
Oct 03 2014	RGLS	Regulus Therapeuti ...	ALNYLAM PHARMACEUTICALS, INC.	10% Owner	Sell	S	6.64	3,750	24,903	6,035,250	6 M to 6 M (-0.06 %)
Oct 03 2014	RGLS	Regulus Therapeuti ...	ALNYLAM PHARMACEUTICALS, INC.	10% Owner	Sell	S	6.71	3,250	21,808	6,039,000	6 M to 6 M (-0.05 %)

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