STANLEY T CROOKE Insider Trading $ISIS IONIS PHARMACEUTICALS INC

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General | Insider Transactions | Monthly Overview

Get the latest insider transactions of STANLEY T CROOKE. STANLEY T CROOKE is Chairman and CEO in IONIS PHARMACEUTICALS INC ($ISIS) and Chairman, CEO and President in IONIS PHARMACEUTICALS INC ($ISIS) and Chairman, President and CEO in IONIS PHARMACEUTICALS INC ($ISIS) and Chairman, President, CEO in IONIS PHARMACEUTICALS INC ($ISIS) and COO, President in IONIS PHARMACEUTICALS INC ($ISIS).

STANLEY T CROOKE in IONIS PHARMACEUTICALS INC

Trading Symbol: ISIS
Industry: PHARMACEUTICAL PREPARATIONS [2834]
Position of STANLEY T CROOKE: Chairman, President and CEO, Chairman and CEO, COO, President, Chairman, CEO and President, Chairman, President, CEO
Holdings: 1,297 shares
Latest Transaction: Jan 29 2015

Last 4 weeks trend: HOLD
Last 3 months trend: HOLD

Latest Insider Trading Transactions of STANLEY T CROOKE in IONIS PHARMACEUTICALS INC

	1 Week	2 Weeks	1 Month	3 Months	6 Months	1 Year	2 Years
No. of Purchases	0	0	0	0	0	0	0
Value of Purchases ($)	0	0	0	0	0	0	0
No. of Sales	0	0	0	0	0	0	0
Value of Sales ($)	0	0	0	0	0	0	0

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Date	Ticker	Company	Owner	Relationship	Transaction	Code	Cost ($)	Shares	Transaction Value ($)	Total Shares	% Holdings
Jan 29 2015	ISIS	IONIS PHARMACEUTIC ...	CROOKE STANLEY T	Chairman and CEO	Option Exercise	M	9.22	1,000	9,220	11,350
Jan 29 2015	ISIS	IONIS PHARMACEUTIC ...	CROOKE STANLEY T	Chairman and CEO	Option Exercise	M	11.27	10,000	112,700	69,163
Jan 29 2015	ISIS	IONIS PHARMACEUTIC ...	CROOKE STANLEY T	Chairman and CEO	Sell	S	72.93	1,000	72,926	1,297	2.3 K to 1.3 K (-43.54 %)
Jan 29 2015	ISIS	IONIS PHARMACEUTIC ...	CROOKE STANLEY T	Chairman and CEO	Buy	M	9.22	1,000	9,220	2,297	1.3 K to 2.3 K (+77.10 %)
Jan 29 2015	ISIS	IONIS PHARMACEUTIC ...	CROOKE STANLEY T	Chairman and CEO	Sell	S	72.93	10,000	729,260	14,642	24.6 K to 14.6 K (-40.58 %)
Jan 29 2015	ISIS	IONIS PHARMACEUTIC ...	CROOKE STANLEY T	Chairman and CEO	Buy	M	11.27	10,000	112,700	24,642	14.6 K to 24.6 K (+68.30 %)
Jan 20 2015	ISIS	IONIS PHARMACEUTIC ...	CROOKE STANLEY T	Chairman and CEO	Option Exercise	M	0.00	354	0	1,062
Jan 20 2015	ISIS	IONIS PHARMACEUTIC ...	CROOKE STANLEY T	Chairman and CEO	Option Exercise	M	0.00	417	0	832
Jan 20 2015	ISIS	IONIS PHARMACEUTIC ...	CROOKE STANLEY T	Chairman and CEO	Option Exercise	M	0.00	316	0	316
Jan 20 2015	ISIS	IONIS PHARMACEUTIC ...	CROOKE STANLEY T	Chairman and CEO	Option Exercise	M	0.00	7,813	0	23,437
Jan 20 2015	ISIS	IONIS PHARMACEUTIC ...	CROOKE STANLEY T	Chairman and CEO	Option Exercise	M	0.00	5,548	0	11,094
Jan 20 2015	ISIS	IONIS PHARMACEUTIC ...	CROOKE STANLEY T	Chairman and CEO	Option Exercise	M	0.00	2,977	0	2,977
Jan 20 2015	ISIS	IONIS PHARMACEUTIC ...	CROOKE STANLEY T	Chairman and CEO	Option Exercise	A	0.00	1,450	0	1,450
Jan 20 2015	ISIS	IONIS PHARMACEUTIC ...	CROOKE STANLEY T	Chairman and CEO	Option Exercise	A	0.00	27,500	0	27,500
Jan 20 2015	ISIS	IONIS PHARMACEUTIC ...	CROOKE STANLEY T	Chairman and CEO	Sell	S	67.96	136	9,243	1,297	1.4 K to 1.3 K (-9.49 %)
Jan 20 2015	ISIS	IONIS PHARMACEUTIC ...	CROOKE STANLEY T	Chairman and CEO	Buy	M	0.00	354	0	1,433	1.1 K to 1.4 K (+32.81 %)
Jan 20 2015	ISIS	IONIS PHARMACEUTIC ...	CROOKE STANLEY T	Chairman and CEO	Sell	S	67.96	160	10,874	1,079	1.2 K to 1.1 K (-12.91 %)
Jan 20 2015	ISIS	IONIS PHARMACEUTIC ...	CROOKE STANLEY T	Chairman and CEO	Buy	M	0.00	417	0	1,239	822 to 1.2 K (+50.73 %)
Jan 20 2015	ISIS	IONIS PHARMACEUTIC ...	CROOKE STANLEY T	Chairman and CEO	Sell	S	67.96	121	8,224	822	943 to 822 (-12.83 %)
Jan 20 2015	ISIS	IONIS PHARMACEUTIC ...	CROOKE STANLEY T	Chairman and CEO	Buy	M	0.00	316	0	943	627 to 943 (+50.40 %)
Jan 20 2015	ISIS	IONIS PHARMACEUTIC ...	CROOKE STANLEY T	Chairman and CEO	Sell	S	67.96	4,130	280,693	14,642	18.8 K to 14.6 K (-22.00 %)
Jan 20 2015	ISIS	IONIS PHARMACEUTIC ...	CROOKE STANLEY T	Chairman and CEO	Buy	M	0.00	7,813	0	18,772	11 K to 18.8 K (+71.29 %)
Jan 20 2015	ISIS	IONIS PHARMACEUTIC ...	CROOKE STANLEY T	Chairman and CEO	Sell	S	67.96	2,933	199,338	10,959	13.9 K to 11 K (-21.11 %)
Jan 20 2015	ISIS	IONIS PHARMACEUTIC ...	CROOKE STANLEY T	Chairman and CEO	Buy	M	0.00	5,548	0	13,892	8.3 K to 13.9 K (+66.49 %)
Jan 20 2015	ISIS	IONIS PHARMACEUTIC ...	CROOKE STANLEY T	Chairman and CEO	Sell	S	67.96	1,574	106,975	8,344	9.9 K to 8.3 K (-15.87 %)
Jan 20 2015	ISIS	IONIS PHARMACEUTIC ...	CROOKE STANLEY T	Chairman and CEO	Buy	M	0.00	2,977	0	9,918	6.9 K to 9.9 K (+42.89 %)
Jan 13 2015	ISIS	IONIS PHARMACEUTIC ...	CROOKE STANLEY T	Chairman and CEO	Option Exercise	M	9.22	1,000	9,220	12,350
Jan 13 2015	ISIS	IONIS PHARMACEUTIC ...	CROOKE STANLEY T	Chairman and CEO	Option Exercise	M	11.27	10,000	112,700	79,163
Jan 13 2015	ISIS	IONIS PHARMACEUTIC ...	CROOKE STANLEY T	Chairman and CEO	Sell	S	73.57	1,000	73,570	627	1.6 K to 627 (-61.46 %)
Jan 13 2015	ISIS	IONIS PHARMACEUTIC ...	CROOKE STANLEY T	Chairman and CEO	Buy	M	9.22	1,000	9,220	1,627	627 to 1.6 K (+159.49 %)
Jan 13 2015	ISIS	IONIS PHARMACEUTIC ...	CROOKE STANLEY T	Chairman and CEO	Sell	S	73.57	10,000	735,700	6,941	16.9 K to 6.9 K (-59.03 %)
Jan 13 2015	ISIS	IONIS PHARMACEUTIC ...	CROOKE STANLEY T	Chairman and CEO	Buy	M	11.27	10,000	112,700	16,941	6.9 K to 16.9 K (+144.07 %)
Jan 08 2015	ISIS	IONIS PHARMACEUTIC ...	CROOKE STANLEY T	Chairman and CEO	Option Exercise	M	9.22	1,000	9,220	13,350
Jan 08 2015	ISIS	IONIS PHARMACEUTIC ...	CROOKE STANLEY T	Chairman and CEO	Option Exercise	M	11.27	10,000	112,700	89,163
Jan 08 2015	ISIS	IONIS PHARMACEUTIC ...	CROOKE STANLEY T	Chairman and CEO	Option Exercise	M	9.22	1,000	9,220	14,350
Jan 08 2015	ISIS	IONIS PHARMACEUTIC ...	CROOKE STANLEY T	Chairman and CEO	Option Exercise	M	11.27	10,000	112,700	99,163
Jan 08 2015	ISIS	IONIS PHARMACEUTIC ...	CROOKE STANLEY T	Chairman and CEO	Sell	S	68.05	1,000	68,048	627	1.6 K to 627 (-61.46 %)
Jan 08 2015	ISIS	IONIS PHARMACEUTIC ...	CROOKE STANLEY T	Chairman and CEO	Buy	M	9.22	1,000	9,220	1,627	627 to 1.6 K (+159.49 %)
Jan 08 2015	ISIS	IONIS PHARMACEUTIC ...	CROOKE STANLEY T	Chairman and CEO	Sell	S	68.05	10,000	680,480	6,941	16.9 K to 6.9 K (-59.03 %)
Jan 08 2015	ISIS	IONIS PHARMACEUTIC ...	CROOKE STANLEY T	Chairman and CEO	Buy	M	11.27	10,000	112,700	16,941	6.9 K to 16.9 K (+144.07 %)
Jan 08 2015	ISIS	IONIS PHARMACEUTIC ...	CROOKE STANLEY T	Chairman and CEO	Sell	S	66.04	1,000	66,038	627	1.6 K to 627 (-61.46 %)
Jan 08 2015	ISIS	IONIS PHARMACEUTIC ...	CROOKE STANLEY T	Chairman and CEO	Buy	M	9.22	1,000	9,220	1,627	627 to 1.6 K (+159.49 %)
Jan 08 2015	ISIS	IONIS PHARMACEUTIC ...	CROOKE STANLEY T	Chairman and CEO	Sell	S	66.04	10,000	660,380	6,941	16.9 K to 6.9 K (-59.03 %)
Jan 08 2015	ISIS	IONIS PHARMACEUTIC ...	CROOKE STANLEY T	Chairman and CEO	Buy	M	11.27	10,000	112,700	16,941	6.9 K to 16.9 K (+144.07 %)
Jan 05 2015	ISIS	IONIS PHARMACEUTIC ...	CROOKE STANLEY T	Chairman and CEO	Option Exercise	M	61.57	8,700	535,659	8,700
Jan 05 2015	ISIS	IONIS PHARMACEUTIC ...	CROOKE STANLEY T	Chairman and CEO	Option Exercise	A	61.57	165,000	10,159,050	165,000
Oct 24 2014	ISIS	IONIS PHARMACEUTIC ...	CROOKE STANLEY T	Chairman and CEO	Option Exercise	M	9.22	1,600	14,752	15,350
Oct 24 2014	ISIS	IONIS PHARMACEUTIC ...	CROOKE STANLEY T	Chairman and CEO	Option Exercise	M	11.27	10,000	112,700	109,163
Oct 24 2014	ISIS	IONIS PHARMACEUTIC ...	CROOKE STANLEY T	Chairman and CEO	Option Exercise	M	14.47	3,000	43,410	0
Oct 24 2014	ISIS	IONIS PHARMACEUTIC ...	CROOKE STANLEY T	Chairman and CEO	Sell	S	42.22	1,600	67,552	627	2.2 K to 627 (-71.85 %)
Oct 24 2014	ISIS	IONIS PHARMACEUTIC ...	CROOKE STANLEY T	Chairman and CEO	Buy	M	9.22	1,600	14,752	2,227	627 to 2.2 K (+255.18 %)
Oct 24 2014	ISIS	IONIS PHARMACEUTIC ...	CROOKE STANLEY T	Chairman and CEO	Sell	S	42.22	10,000	422,200	6,941	16.9 K to 6.9 K (-59.03 %)
Oct 24 2014	ISIS	IONIS PHARMACEUTIC ...	CROOKE STANLEY T	Chairman and CEO	Buy	M	11.27	10,000	112,700	16,941	6.9 K to 16.9 K (+144.07 %)
Oct 24 2014	ISIS	IONIS PHARMACEUTIC ...	CROOKE STANLEY T	Chairman and CEO	Sell	S	42.22	3,000	126,660	6,941	9.9 K to 6.9 K (-30.18 %)
Oct 24 2014	ISIS	IONIS PHARMACEUTIC ...	CROOKE STANLEY T	Chairman and CEO	Buy	M	14.47	3,000	43,410	9,941	6.9 K to 9.9 K (+43.22 %)
Oct 03 2014	ISIS	IONIS PHARMACEUTIC ...	CROOKE STANLEY T	Chairman and CEO	Option Exercise	M	9.22	1,000	9,220	16,950
Oct 03 2014	ISIS	IONIS PHARMACEUTIC ...	CROOKE STANLEY T	Chairman and CEO	Option Exercise	M	14.47	13,000	188,110	3,000
Oct 03 2014	ISIS	IONIS PHARMACEUTIC ...	CROOKE STANLEY T	Chairman and CEO	Option Exercise	M	9.22	800	7,376	17,950
Oct 03 2014	ISIS	IONIS PHARMACEUTIC ...	CROOKE STANLEY T	Chairman and CEO	Option Exercise	M	11.27	1,200	13,524	1,000
Oct 03 2014	ISIS	IONIS PHARMACEUTIC ...	CROOKE STANLEY T	Chairman and CEO	Option Exercise	M	14.47	20,000	289,400	16,000
Oct 03 2014	ISIS	IONIS PHARMACEUTIC ...	CROOKE STANLEY T	Chairman and CEO	Sell	S	39.49	1,000	39,487	627	1.6 K to 627 (-61.46 %)
Oct 03 2014	ISIS	IONIS PHARMACEUTIC ...	CROOKE STANLEY T	Chairman and CEO	Buy	M	9.22	1,000	9,220	1,627	627 to 1.6 K (+159.49 %)
Oct 03 2014	ISIS	IONIS PHARMACEUTIC ...	CROOKE STANLEY T	Chairman and CEO	Sell	S	39.49	13,000	513,331	6,941	19.9 K to 6.9 K (-65.19 %)
Oct 03 2014	ISIS	IONIS PHARMACEUTIC ...	CROOKE STANLEY T	Chairman and CEO	Buy	M	14.47	13,000	188,110	19,941	6.9 K to 19.9 K (+187.29 %)
Oct 03 2014	ISIS	IONIS PHARMACEUTIC ...	CROOKE STANLEY T	Chairman and CEO	Sell	S	37.91	800	30,329	627	1.4 K to 627 (-56.06 %)
Oct 03 2014	ISIS	IONIS PHARMACEUTIC ...	CROOKE STANLEY T	Chairman and CEO	Buy	M	9.22	800	7,376	1,427	627 to 1.4 K (+127.59 %)
Oct 03 2014	ISIS	IONIS PHARMACEUTIC ...	CROOKE STANLEY T	Chairman and CEO	Sell	S	37.91	1,200	45,493	627	1.8 K to 627 (-65.68 %)
Oct 03 2014	ISIS	IONIS PHARMACEUTIC ...	CROOKE STANLEY T	Chairman and CEO	Buy	M	11.27	1,200	13,524	1,827	627 to 1.8 K (+191.39 %)
Oct 03 2014	ISIS	IONIS PHARMACEUTIC ...	CROOKE STANLEY T	Chairman and CEO	Sell	S	37.91	20,000	758,220	6,941	26.9 K to 6.9 K (-74.24 %)
Oct 03 2014	ISIS	IONIS PHARMACEUTIC ...	CROOKE STANLEY T	Chairman and CEO	Buy	M	14.47	20,000	289,400	26,941	6.9 K to 26.9 K (+288.14 %)
Aug 15 2014	ISIS	IONIS PHARMACEUTIC ...	CROOKE STANLEY T	Chairman, President ...	Option Exercise	M	11.27	1,600	18,032	2,200
Aug 15 2014	ISIS	IONIS PHARMACEUTIC ...	CROOKE STANLEY T	Chairman, President ...	Option Exercise	M	14.47	15,500	224,285	36,000
Aug 15 2014	ISIS	IONIS PHARMACEUTIC ...	CROOKE STANLEY T	Chairman, President ...	Sell	S	35.45	1,600	56,726	627	2.2 K to 627 (-71.85 %)
Aug 15 2014	ISIS	IONIS PHARMACEUTIC ...	CROOKE STANLEY T	Chairman, President ...	Buy	M	11.27	1,600	18,032	2,227	627 to 2.2 K (+255.18 %)
Aug 15 2014	ISIS	IONIS PHARMACEUTIC ...	CROOKE STANLEY T	Chairman, President ...	Sell	S	35.45	15,500	549,537	6,941	22.4 K to 6.9 K (-69.07 %)
Aug 15 2014	ISIS	IONIS PHARMACEUTIC ...	CROOKE STANLEY T	Chairman, President ...	Buy	M	14.47	15,500	224,285	22,441	6.9 K to 22.4 K (+223.31 %)
Aug 01 2014	ISIS	IONIS PHARMACEUTIC ...	CROOKE STANLEY T	Chairman, President ...	Option Exercise	M	11.27	1,000	11,270	3,800
Aug 01 2014	ISIS	IONIS PHARMACEUTIC ...	CROOKE STANLEY T	Chairman, President ...	Option Exercise	M	14.47	15,000	217,050	51,500
Aug 01 2014	ISIS	IONIS PHARMACEUTIC ...	CROOKE STANLEY T	Chairman, President ...	Sell	S	30.53	1,000	30,525	627	1.6 K to 627 (-61.46 %)
Aug 01 2014	ISIS	IONIS PHARMACEUTIC ...	CROOKE STANLEY T	Chairman, President ...	Buy	M	11.27	1,000	11,270	1,627	627 to 1.6 K (+159.49 %)
Aug 01 2014	ISIS	IONIS PHARMACEUTIC ...	CROOKE STANLEY T	Chairman, President ...	Sell	S	30.53	15,000	457,875	6,941	21.9 K to 6.9 K (-68.37 %)
Aug 01 2014	ISIS	IONIS PHARMACEUTIC ...	CROOKE STANLEY T	Chairman, President ...	Buy	M	14.47	15,000	217,050	21,941	6.9 K to 21.9 K (+216.11 %)
Jul 02 2014	ISIS	IONIS PHARMACEUTIC ...	CROOKE STANLEY T	Chairman and CEO	Option Exercise	M	11.27	1,800	20,286	4,800
Jul 02 2014	ISIS	IONIS PHARMACEUTIC ...	CROOKE STANLEY T	Chairman and CEO	Option Exercise	M	14.47	200	2,894	0
Jul 02 2014	ISIS	IONIS PHARMACEUTIC ...	CROOKE STANLEY T	Chairman and CEO	Option Exercise	M	14.47	15,500	224,285	66,500
Jul 02 2014	ISIS	IONIS PHARMACEUTIC ...	CROOKE STANLEY T	Chairman and CEO	Sell	S	35.55	1,800	63,990	627	2.4 K to 627 (-74.17 %)
Jul 02 2014	ISIS	IONIS PHARMACEUTIC ...	CROOKE STANLEY T	Chairman and CEO	Buy	M	11.27	1,800	20,286	2,427	627 to 2.4 K (+287.08 %)
Jul 02 2014	ISIS	IONIS PHARMACEUTIC ...	CROOKE STANLEY T	Chairman and CEO	Sell	S	35.55	200	7,110	627	827 to 627 (-24.18 %)
Jul 02 2014	ISIS	IONIS PHARMACEUTIC ...	CROOKE STANLEY T	Chairman and CEO	Buy	M	14.47	200	2,894	827	627 to 827 (+31.90 %)
Jul 02 2014	ISIS	IONIS PHARMACEUTIC ...	CROOKE STANLEY T	Chairman and CEO	Sell	S	35.58	15,500	551,459	6,941	22.4 K to 6.9 K (-69.07 %)
Jul 02 2014	ISIS	IONIS PHARMACEUTIC ...	CROOKE STANLEY T	Chairman and CEO	Buy	M	14.47	15,500	224,285	22,441	6.9 K to 22.4 K (+223.31 %)
Jun 20 2014	ISIS	IONIS PHARMACEUTIC ...	CROOKE STANLEY T	Chairman, President ...	Option Exercise	M	14.47	11,000	159,170	82,000
Jun 20 2014	ISIS	IONIS PHARMACEUTIC ...	CROOKE STANLEY T	Chairman, President ...	Sell	S	35.10	11,000	386,111	6,941	17.9 K to 6.9 K (-61.31 %)
Jun 20 2014	ISIS	IONIS PHARMACEUTIC ...	CROOKE STANLEY T	Chairman, President ...	Buy	M	14.47	11,000	159,170	17,941	6.9 K to 17.9 K (+158.48 %)
Jun 12 2014	ISIS	IONIS PHARMACEUTIC ...	CROOKE STANLEY T	Chairman, President ...	Option Exercise	M	14.47	1,000	14,470	200
Jun 12 2014	ISIS	IONIS PHARMACEUTIC ...	CROOKE STANLEY T	Chairman, President ...	Option Exercise	M	14.47	10,000	144,700	93,000
Jun 12 2014	ISIS	IONIS PHARMACEUTIC ...	CROOKE STANLEY T	Chairman, President ...	Sell	S	33.46	1,000	33,455	627	1.6 K to 627 (-61.46 %)
Jun 12 2014	ISIS	IONIS PHARMACEUTIC ...	CROOKE STANLEY T	Chairman, President ...	Buy	M	14.47	1,000	14,470	1,627	627 to 1.6 K (+159.49 %)
Jun 12 2014	ISIS	IONIS PHARMACEUTIC ...	CROOKE STANLEY T	Chairman, President ...	Sell	S	33.46	10,000	334,550	6,941	16.9 K to 6.9 K (-59.03 %)
Jun 12 2014	ISIS	IONIS PHARMACEUTIC ...	CROOKE STANLEY T	Chairman, President ...	Buy	M	14.47	10,000	144,700	16,941	6.9 K to 16.9 K (+144.07 %)
Apr 04 2014	ISIS	IONIS PHARMACEUTIC ...	CROOKE STANLEY T	Chairman, President ...	Option Exercise	M	14.47	1,800	26,046	1,200
Apr 04 2014	ISIS	IONIS PHARMACEUTIC ...	CROOKE STANLEY T	Chairman, President ...	Option Exercise	M	14.47	7,000	101,290	103,000
Apr 04 2014	ISIS	IONIS PHARMACEUTIC ...	CROOKE STANLEY T	Chairman, President ...	Sell	S	43.65	1,800	78,566	627	2.4 K to 627 (-74.17 %)
Apr 04 2014	ISIS	IONIS PHARMACEUTIC ...	CROOKE STANLEY T	Chairman, President ...	Buy	M	14.47	1,800	26,046	2,427	627 to 2.4 K (+287.08 %)
Apr 04 2014	ISIS	IONIS PHARMACEUTIC ...	CROOKE STANLEY T	Chairman, President ...	Sell	S	43.65	7,000	305,536	6,941	13.9 K to 6.9 K (-50.21 %)
Apr 04 2014	ISIS	IONIS PHARMACEUTIC ...	CROOKE STANLEY T	Chairman, President ...	Buy	M	14.47	7,000	101,290	13,941	6.9 K to 13.9 K (+100.85 %)
Jan 17 2014	ISIS	IONIS PHARMACEUTIC ...	CROOKE STANLEY T	Chairman and CEO	Option Exercise	M	0.00	317	0	632
Jan 17 2014	ISIS	IONIS PHARMACEUTIC ...	CROOKE STANLEY T	Chairman and CEO	Option Exercise	M	0.00	417	0	1,249
Jan 17 2014	ISIS	IONIS PHARMACEUTIC ...	CROOKE STANLEY T	Chairman and CEO	Option Exercise	M	0.00	2,978	0	5,954
Jan 17 2014	ISIS	IONIS PHARMACEUTIC ...	CROOKE STANLEY T	Chairman and CEO	Option Exercise	M	0.00	5,548	0	16,642
Jan 17 2014	ISIS	IONIS PHARMACEUTIC ...	CROOKE STANLEY T	Chairman and CEO	Option Exercise	A	0.00	1,416	0	1,416
Jan 17 2014	ISIS	IONIS PHARMACEUTIC ...	CROOKE STANLEY T	Chairman and CEO	Option Exercise	A	0.00	31,250	0	31,250
Jan 17 2014	ISIS	IONIS PHARMACEUTIC ...	CROOKE STANLEY T	Chairman and CEO	Sell	S	47.08	121	5,697	627	748 to 627 (-16.18 %)
Jan 17 2014	ISIS	IONIS PHARMACEUTIC ...	CROOKE STANLEY T	Chairman and CEO	Buy	M	0.00	317	0	748	431 to 748 (+73.55 %)
Jan 17 2014	ISIS	IONIS PHARMACEUTIC ...	CROOKE STANLEY T	Chairman and CEO	Sell	S	47.08	160	7,533	431	591 to 431 (-27.07 %)
Jan 17 2014	ISIS	IONIS PHARMACEUTIC ...	CROOKE STANLEY T	Chairman and CEO	Buy	M	0.00	417	0	591	174 to 591 (+239.66 %)
Jan 17 2014	ISIS	IONIS PHARMACEUTIC ...	CROOKE STANLEY T	Chairman and CEO	Sell	S	47.08	1,134	53,390	6,941	8.1 K to 6.9 K (-14.04 %)
Jan 17 2014	ISIS	IONIS PHARMACEUTIC ...	CROOKE STANLEY T	Chairman and CEO	Buy	M	0.00	2,978	0	8,075	5.1 K to 8.1 K (+58.43 %)
Jan 17 2014	ISIS	IONIS PHARMACEUTIC ...	CROOKE STANLEY T	Chairman and CEO	Sell	S	47.08	2,112	99,435	5,097	7.2 K to 5.1 K (-29.30 %)
Jan 17 2014	ISIS	IONIS PHARMACEUTIC ...	CROOKE STANLEY T	Chairman and CEO	Buy	M	0.00	5,548	0	7,209	1.7 K to 7.2 K (+334.02 %)
Jan 10 2014	ISIS	IONIS PHARMACEUTIC ...	CROOKE STANLEY T	Chairman, President ...	Option Exercise	M	14.47	1,500	21,705	3,000
Jan 10 2014	ISIS	IONIS PHARMACEUTIC ...	CROOKE STANLEY T	Chairman, President ...	Option Exercise	M	14.47	11,000	159,170	110,000
Jan 10 2014	ISIS	IONIS PHARMACEUTIC ...	CROOKE STANLEY T	Chairman, President ...	Sell	S	40.05	1,500	60,078	174	1.7 K to 174 (-89.61 %)
Jan 10 2014	ISIS	IONIS PHARMACEUTIC ...	CROOKE STANLEY T	Chairman, President ...	Buy	M	14.47	1,500	21,705	1,674	174 to 1.7 K (+862.07 %)
Jan 10 2014	ISIS	IONIS PHARMACEUTIC ...	CROOKE STANLEY T	Chairman, President ...	Sell	S	40.05	11,000	440,572	1,661	12.7 K to 1.7 K (-86.88 %)
Jan 10 2014	ISIS	IONIS PHARMACEUTIC ...	CROOKE STANLEY T	Chairman, President ...	Buy	M	14.47	11,000	159,170	12,661	1.7 K to 12.7 K (+662.25 %)
Jan 03 2014	ISIS	IONIS PHARMACEUTIC ...	CROOKE STANLEY T	Chairman, President ...	Option Exercise	A	39.87	8,500	338,895	8,500
Jan 03 2014	ISIS	IONIS PHARMACEUTIC ...	CROOKE STANLEY T	Chairman, President ...	Option Exercise	A	39.87	187,500	7,475,625	187,500
Jan 03 2014	ISIS	IONIS PHARMACEUTIC ...	CROOKE STANLEY T	Chairman, President ...	Sell	S	39.25	2,500	98,133	174	2.7 K to 174 (-93.49 %)
Jan 03 2014	ISIS	IONIS PHARMACEUTIC ...	CROOKE STANLEY T	Chairman, President ...	Buy	M	14.47	2,500	36,175	2,674	174 to 2.7 K (+1,436.78 %)
Jan 03 2014	ISIS	IONIS PHARMACEUTIC ...	CROOKE STANLEY T	Chairman, President ...	Sell	S	40.00	4,000	160,000	1,661	5.7 K to 1.7 K (-70.66 %)
Jan 03 2014	ISIS	IONIS PHARMACEUTIC ...	CROOKE STANLEY T	Chairman, President ...	Buy	M	14.47	4,000	57,880	5,661	1.7 K to 5.7 K (+240.82 %)
Jan 03 2014	ISIS	IONIS PHARMACEUTIC ...	CROOKE STANLEY T	Chairman, President ...	Sell	S	39.25	25,000	981,325	1,661	26.7 K to 1.7 K (-93.77 %)
Jan 03 2014	ISIS	IONIS PHARMACEUTIC ...	CROOKE STANLEY T	Chairman, President ...	Buy	M	14.47	25,000	361,750	26,661	1.7 K to 26.7 K (+1,505.12 %)
Sep 23 2013	ISIS	IONIS PHARMACEUTIC ...	CROOKE STANLEY T	Chairman and CEO	Option Exercise	M	11.12	8,740	97,189	0
Sep 23 2013	ISIS	IONIS PHARMACEUTIC ...	CROOKE STANLEY T	Chairman and CEO	Option Exercise	M	11.12	50,000	556,000	8,740
Sep 23 2013	ISIS	IONIS PHARMACEUTIC ...	CROOKE STANLEY T	Chairman and CEO	Sell	S	35.90	8,740	313,749	1,661	10.4 K to 1.7 K (-84.03 %)
Sep 23 2013	ISIS	IONIS PHARMACEUTIC ...	CROOKE STANLEY T	Chairman and CEO	Buy	M	11.12	8,740	97,189	10,401	1.7 K to 10.4 K (+526.19 %)
Sep 23 2013	ISIS	IONIS PHARMACEUTIC ...	CROOKE STANLEY T	Chairman and CEO	Sell	S	35.02	30,000	1,050,600	1,661	31.7 K to 1.7 K (-94.75 %)
Sep 23 2013	ISIS	IONIS PHARMACEUTIC ...	CROOKE STANLEY T	Chairman and CEO	Buy	M	11.12	30,000	333,600	31,661	1.7 K to 31.7 K (+1,806.14 %)
Sep 23 2013	ISIS	IONIS PHARMACEUTIC ...	CROOKE STANLEY T	Chairman and CEO	Sell	S	35.12	20,000	702,480	1,661	21.7 K to 1.7 K (-92.33 %)
Sep 23 2013	ISIS	IONIS PHARMACEUTIC ...	CROOKE STANLEY T	Chairman and CEO	Buy	M	11.12	20,000	222,400	21,661	1.7 K to 21.7 K (+1,204.09 %)
Sep 11 2013	ISIS	IONIS PHARMACEUTIC ...	CROOKE STANLEY T	COO, President	Option Exercise	M	11.12	26,615	295,959	58,740
Sep 11 2013	ISIS	IONIS PHARMACEUTIC ...	CROOKE STANLEY T	COO, President	Sell	S	31.18	20,000	623,620	725,391	745.4 K to 725.4 K (-2.68 %)
Sep 11 2013	ISIS	IONIS PHARMACEUTIC ...	CROOKE STANLEY T	COO, President	Sell	S	31.65	30,000	949,440	745,391	775.4 K to 745.4 K (-3.87 %)
Sep 11 2013	ISIS	IONIS PHARMACEUTIC ...	CROOKE STANLEY T	COO, President	Sell	S	30.42	26,615	809,495	1,661	28.3 K to 1.7 K (-94.13 %)
Sep 11 2013	ISIS	IONIS PHARMACEUTIC ...	CROOKE STANLEY T	COO, President	Buy	M	11.12	26,615	295,959	28,276	1.7 K to 28.3 K (+1,602.35 %)
Jul 25 2013	ISIS	IONIS PHARMACEUTIC ...	CROOKE STANLEY T	COO, President	Option Exercise	M	11.12	11,500	127,880	85,355
Jul 25 2013	ISIS	IONIS PHARMACEUTIC ...	CROOKE STANLEY T	COO, President	Sell	S	30.00	11,500	345,000	1,661	13.2 K to 1.7 K (-87.38 %)
Jul 25 2013	ISIS	IONIS PHARMACEUTIC ...	CROOKE STANLEY T	COO, President	Buy	M	11.12	11,500	127,880	13,161	1.7 K to 13.2 K (+692.35 %)

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