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General | Insiders | Insider Transactions | Monthly Overview | Weekly Overview

Overview of all insider trading transactions in INSPIRE PHARMACEUTICALS INC. Get notifications about new insider transactions in INSPIRE PHARMACEUTICALS INC for free.

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Date	Ticker	Company	Owner	Relationship	Transaction	Code	Cost ($)	Shares	Transaction Value ($)	Total Shares	% Holdings
Mar 22 2010	ISPH	INSPIRE PHARMACEUT ...	STAAB THOMAS R II	CFO & Treasurer	Option Exercise	A	6.08	22,000	133,760	22,000
Mar 03 2010	ISPH	INSPIRE PHARMACEUT ...	YERXA BENJAMIN R	EVP & Chf, Research ...	Sell	S	6.10	124	756	56,257	56.4 K to 56.3 K (-0.22 %)
Mar 03 2010	ISPH	INSPIRE PHARMACEUT ...	YERXA BENJAMIN R	EVP & Chf, Research ...	Sell	S	6.11	100	611	56,381	56.5 K to 56.4 K (-0.18 %)
Mar 03 2010	ISPH	INSPIRE PHARMACEUT ...	YERXA BENJAMIN R	EVP & Chf, Research ...	Sell	S	6.13	576	3,531	56,481	57.1 K to 56.5 K (-1.01 %)
Mar 03 2010	ISPH	INSPIRE PHARMACEUT ...	YERXA BENJAMIN R	EVP & Chf, Research ...	Sell	S	6.14	100	614	57,057	57.2 K to 57.1 K (-0.17 %)
Mar 03 2010	ISPH	INSPIRE PHARMACEUT ...	YERXA BENJAMIN R	EVP & Chf, Research ...	Sell	S	6.15	604	3,715	57,157	57.8 K to 57.2 K (-1.05 %)
Mar 03 2010	ISPH	INSPIRE PHARMACEUT ...	YERXA BENJAMIN R	EVP & Chf, Research ...	Sell	S	6.16	496	3,055	57,761	58.3 K to 57.8 K (-0.85 %)
Mar 19 2010	ISPH	INSPIRE PHARMACEUT ...	ADAMS ADRIAN	President and CEO	Grant	A	0.00	650,000	0	650,000	0 to 650 K
Mar 02 2010	ISPH	INSPIRE PHARMACEUT ...	ABERCROMBIE GEORGE B	Director	Option Exercise	A	0.00	1,592	0	1,592
Mar 02 2010	ISPH	INSPIRE PHARMACEUT ...	ABERCROMBIE GEORGE B	Director	Option Exercise	A	0.00	12,739	0	12,739
Mar 02 2010	ISPH	INSPIRE PHARMACEUT ...	ABERCROMBIE GEORGE B	Director	Option Exercise	A	6.28	2,371	14,890	2,371
Mar 02 2010	ISPH	INSPIRE PHARMACEUT ...	ABERCROMBIE GEORGE B	Director	Option Exercise	A	6.28	18,970	119,132	18,970
Feb 23 2010	ISPH	INSPIRE PHARMACEUT ...	ADAMS ADRIAN	President and CEO	Option Exercise	A	6.35	350,000	2,222,500	350,000
Mar 02 2010	ISPH	INSPIRE PHARMACEUT ...	ABERCROMBIE GEORGE B	Director	Option Exercise	A	0.00	1,592	0	1,592
Mar 02 2010	ISPH	INSPIRE PHARMACEUT ...	ABERCROMBIE GEORGE B	Director	Option Exercise	A	0.00	12,739	0	12,739
Mar 02 2010	ISPH	INSPIRE PHARMACEUT ...	ABERCROMBIE GEORGE B	Director	Option Exercise	A	6.28	2,371	14,890	2,371
Mar 02 2010	ISPH	INSPIRE PHARMACEUT ...	ABERCROMBIE GEORGE B	Director	Option Exercise	A	6.28	18,970	119,132	18,970
Jan 05 2010	ISPH	INSPIRE PHARMACEUT ...	YERXA BENJAMIN R	EVP & Chf, Research ...	Sell	S	5.55	100	555	60,257	60.4 K to 60.3 K (-0.17 %)
Jan 05 2010	ISPH	INSPIRE PHARMACEUT ...	YERXA BENJAMIN R	EVP & Chf, Research ...	Sell	S	5.58	94	525	60,357	60.5 K to 60.4 K (-0.16 %)
Jan 05 2010	ISPH	INSPIRE PHARMACEUT ...	YERXA BENJAMIN R	EVP & Chf, Research ...	Sell	S	5.59	106	593	60,451	60.6 K to 60.5 K (-0.18 %)
Jan 05 2010	ISPH	INSPIRE PHARMACEUT ...	YERXA BENJAMIN R	EVP & Chf, Research ...	Sell	S	5.60	200	1,120	60,557	60.8 K to 60.6 K (-0.33 %)
Jan 05 2010	ISPH	INSPIRE PHARMACEUT ...	YERXA BENJAMIN R	EVP & Chf, Research ...	Sell	S	5.61	1,100	6,171	60,757	61.9 K to 60.8 K (-1.78 %)
Jan 05 2010	ISPH	INSPIRE PHARMACEUT ...	YERXA BENJAMIN R	EVP & Chf, Research ...	Sell	S	5.62	400	2,248	61,857	62.3 K to 61.9 K (-0.64 %)
Feb 02 2010	ISPH	INSPIRE PHARMACEUT ...	YERXA BENJAMIN R	EVP & Chf, Research ...	Sell	S	5.40	1,200	6,480	58,257	59.5 K to 58.3 K (-2.02 %)
Feb 02 2010	ISPH	INSPIRE PHARMACEUT ...	YERXA BENJAMIN R	EVP & Chf, Research ...	Sell	S	5.41	455	2,462	59,457	59.9 K to 59.5 K (-0.76 %)
Feb 02 2010	ISPH	INSPIRE PHARMACEUT ...	YERXA BENJAMIN R	EVP & Chf, Research ...	Sell	S	5.43	45	244	59,912	60 K to 59.9 K (-0.08 %)
Feb 02 2010	ISPH	INSPIRE PHARMACEUT ...	YERXA BENJAMIN R	EVP & Chf, Research ...	Sell	S	5.44	100	544	59,957	60.1 K to 60 K (-0.17 %)
Feb 02 2010	ISPH	INSPIRE PHARMACEUT ...	YERXA BENJAMIN R	EVP & Chf, Research ...	Sell	S	5.46	200	1,092	60,057	60.3 K to 60.1 K (-0.33 %)
Dec 08 2009	ISPH	INSPIRE PHARMACEUT ...	SHAFFER CHRISTY L	President & CEO	Sell	S	6.00	3,500	21,000	356,497	360 K to 356.5 K (-0.97 %)
Dec 08 2009	ISPH	INSPIRE PHARMACEUT ...	SHAFFER CHRISTY L	President & CEO	Sell	S	6.00	1,500	9,000	359,997	361.5 K to 360 K (-0.41 %)
Dec 02 2009	ISPH	INSPIRE PHARMACEUT ...	YERXA BENJAMIN R	EVP & Chf, Research ...	Sell	S	5.63	100	563	62,257	62.4 K to 62.3 K (-0.16 %)
Dec 02 2009	ISPH	INSPIRE PHARMACEUT ...	YERXA BENJAMIN R	EVP & Chf, Research ...	Sell	S	5.65	100	565	62,357	62.5 K to 62.4 K (-0.16 %)
Dec 02 2009	ISPH	INSPIRE PHARMACEUT ...	YERXA BENJAMIN R	EVP & Chf, Research ...	Sell	S	5.66	200	1,132	62,457	62.7 K to 62.5 K (-0.32 %)
Dec 02 2009	ISPH	INSPIRE PHARMACEUT ...	YERXA BENJAMIN R	EVP & Chf, Research ...	Sell	S	5.68	300	1,704	62,657	63 K to 62.7 K (-0.48 %)
Dec 02 2009	ISPH	INSPIRE PHARMACEUT ...	YERXA BENJAMIN R	EVP & Chf, Research ...	Sell	S	5.69	200	1,138	62,957	63.2 K to 63 K (-0.32 %)
Dec 02 2009	ISPH	INSPIRE PHARMACEUT ...	YERXA BENJAMIN R	EVP & Chf, Research ...	Sell	S	5.70	282	1,607	63,157	63.4 K to 63.2 K (-0.44 %)
Dec 02 2009	ISPH	INSPIRE PHARMACEUT ...	YERXA BENJAMIN R	EVP & Chf, Research ...	Sell	S	5.71	200	1,142	63,439	63.6 K to 63.4 K (-0.31 %)
Dec 02 2009	ISPH	INSPIRE PHARMACEUT ...	YERXA BENJAMIN R	EVP & Chf, Research ...	Sell	S	5.72	300	1,716	63,639	63.9 K to 63.6 K (-0.47 %)
Dec 02 2009	ISPH	INSPIRE PHARMACEUT ...	YERXA BENJAMIN R	EVP & Chf, Research ...	Sell	S	5.73	100	573	63,939	64 K to 63.9 K (-0.16 %)
Dec 02 2009	ISPH	INSPIRE PHARMACEUT ...	YERXA BENJAMIN R	EVP & Chf, Research ...	Sell	S	5.74	50	287	64,039	64.1 K to 64 K (-0.08 %)
Dec 02 2009	ISPH	INSPIRE PHARMACEUT ...	YERXA BENJAMIN R	EVP & Chf, Research ...	Sell	S	5.76	168	968	64,089	64.3 K to 64.1 K (-0.26 %)
Nov 13 2009	ISPH	INSPIRE PHARMACEUT ...	SHAFFER CHRISTY L	President & CEO	Option Exercise	A	5.10	29,500	150,450	29,500
Nov 13 2009	ISPH	INSPIRE PHARMACEUT ...	Brazzell Romulus K	EVP & Head, Ophthal ...	Option Exercise	A	5.10	13,250	67,575	13,250
Nov 13 2009	ISPH	INSPIRE PHARMACEUT ...	SCHACHLE JOSEPH K	EVP, Chief Commerci ...	Option Exercise	A	5.10	13,250	67,575	13,250
Nov 13 2009	ISPH	INSPIRE PHARMACEUT ...	Spagnardi Joseph M	Senior VP, GC & Sec ...	Option Exercise	A	5.10	10,250	52,275	10,250
Nov 13 2009	ISPH	INSPIRE PHARMACEUT ...	STAAB THOMAS R II	CFO & Treasurer	Option Exercise	A	5.10	13,250	67,575	13,250
Nov 13 2009	ISPH	INSPIRE PHARMACEUT ...	YERXA BENJAMIN R	EVP & Chf, Research ...	Option Exercise	A	5.10	13,250	67,575	13,250
Oct 01 2009	ISPH	INSPIRE PHARMACEUT ...	YERXA BENJAMIN R	EVP & Chf, Research ...	Sell	S	5.17	200	1,034	66,257	66.5 K to 66.3 K (-0.30 %)
Oct 01 2009	ISPH	INSPIRE PHARMACEUT ...	YERXA BENJAMIN R	EVP & Chf, Research ...	Sell	S	5.19	400	2,076	66,457	66.9 K to 66.5 K (-0.60 %)
Oct 01 2009	ISPH	INSPIRE PHARMACEUT ...	YERXA BENJAMIN R	EVP & Chf, Research ...	Sell	S	5.20	300	1,560	66,857	67.2 K to 66.9 K (-0.45 %)
Oct 01 2009	ISPH	INSPIRE PHARMACEUT ...	YERXA BENJAMIN R	EVP & Chf, Research ...	Sell	S	5.21	1,100	5,731	67,157	68.3 K to 67.2 K (-1.61 %)
Nov 03 2009	ISPH	INSPIRE PHARMACEUT ...	YERXA BENJAMIN R	EVP & Chf, Research ...	Sell	S	4.54	300	1,362	64,257	64.6 K to 64.3 K (-0.46 %)
Nov 03 2009	ISPH	INSPIRE PHARMACEUT ...	YERXA BENJAMIN R	EVP & Chf, Research ...	Sell	S	4.55	600	2,730	64,557	65.2 K to 64.6 K (-0.92 %)
Nov 03 2009	ISPH	INSPIRE PHARMACEUT ...	YERXA BENJAMIN R	EVP & Chf, Research ...	Sell	S	4.56	900	4,104	65,157	66.1 K to 65.2 K (-1.36 %)
Nov 03 2009	ISPH	INSPIRE PHARMACEUT ...	YERXA BENJAMIN R	EVP & Chf, Research ...	Sell	S	4.58	200	916	66,057	66.3 K to 66.1 K (-0.30 %)
Sep 01 2009	ISPH	INSPIRE PHARMACEUT ...	YERXA BENJAMIN R	EVP & Chf, Research ...	Sell	S	5.62	48	270	68,257	68.3 K to 68.3 K (-0.07 %)
Sep 01 2009	ISPH	INSPIRE PHARMACEUT ...	YERXA BENJAMIN R	EVP & Chf, Research ...	Sell	S	5.67	1,000	5,670	68,305	69.3 K to 68.3 K (-1.44 %)
Sep 01 2009	ISPH	INSPIRE PHARMACEUT ...	YERXA BENJAMIN R	EVP & Chf, Research ...	Sell	S	5.68	552	3,135	69,305	69.9 K to 69.3 K (-0.79 %)
Sep 01 2009	ISPH	INSPIRE PHARMACEUT ...	YERXA BENJAMIN R	EVP & Chf, Research ...	Sell	S	5.69	100	569	69,857	70 K to 69.9 K (-0.14 %)
Sep 01 2009	ISPH	INSPIRE PHARMACEUT ...	YERXA BENJAMIN R	EVP & Chf, Research ...	Sell	S	5.70	137	781	69,957	70.1 K to 70 K (-0.20 %)
Sep 01 2009	ISPH	INSPIRE PHARMACEUT ...	YERXA BENJAMIN R	EVP & Chf, Research ...	Sell	S	5.71	100	571	70,094	70.2 K to 70.1 K (-0.14 %)
Sep 01 2009	ISPH	INSPIRE PHARMACEUT ...	YERXA BENJAMIN R	EVP & Chf, Research ...	Sell	S	5.73	63	361	70,194	70.3 K to 70.2 K (-0.09 %)
Aug 25 2009	ISPH	INSPIRE PHARMACEUT ...	SHAFFER CHRISTY L	President & CEO	Sell	S	6.01	3,700	22,237	361,497	365.2 K to 361.5 K (-1.01 %)
Aug 25 2009	ISPH	INSPIRE PHARMACEUT ...	SHAFFER CHRISTY L	President & CEO	Sell	S	6.02	2,900	17,458	365,197	368.1 K to 365.2 K (-0.79 %)
Aug 25 2009	ISPH	INSPIRE PHARMACEUT ...	SHAFFER CHRISTY L	President & CEO	Sell	S	6.03	1,200	7,236	368,097	369.3 K to 368.1 K (-0.32 %)
Aug 25 2009	ISPH	INSPIRE PHARMACEUT ...	SHAFFER CHRISTY L	President & CEO	Sell	S	6.04	400	2,416	369,297	369.7 K to 369.3 K (-0.11 %)
Aug 25 2009	ISPH	INSPIRE PHARMACEUT ...	SHAFFER CHRISTY L	President & CEO	Sell	S	6.05	1,800	10,890	369,697	371.5 K to 369.7 K (-0.48 %)
Aug 13 2009	ISPH	INSPIRE PHARMACEUT ...	YERXA BENJAMIN R	EVP & Chf, Research ...	Option Exercise	A	4.55	13,250	60,288	13,250
Aug 13 2009	ISPH	INSPIRE PHARMACEUT ...	STAAB THOMAS R II	CFO & Treasurer	Option Exercise	A	4.55	13,250	60,288	13,250
Aug 13 2009	ISPH	INSPIRE PHARMACEUT ...	Spagnardi Joseph M	Senior VP, GC & Sec ...	Option Exercise	A	4.55	10,250	46,638	10,250
Aug 13 2009	ISPH	INSPIRE PHARMACEUT ...	SHAFFER CHRISTY L	President & CEO	Option Exercise	A	4.55	29,500	134,225	29,500
Aug 13 2009	ISPH	INSPIRE PHARMACEUT ...	Brazzell Romulus K	EVP & Head, Ophthal ...	Option Exercise	A	4.55	13,250	60,288	13,250
Aug 13 2009	ISPH	INSPIRE PHARMACEUT ...	SCHACHLE JOSEPH K	EVP, Chief Commerci ...	Option Exercise	A	4.55	13,250	60,288	13,250
Aug 10 2009	ISPH	INSPIRE PHARMACEUT ...	Warburg Pincus Private Equity ...	10% Owner	Buy	P	4.50	8,888,888	39,999,996	22,907,488	14 M to 22.9 M (+63.41 %)
Aug 10 2009	ISPH	INSPIRE PHARMACEUT ...	LEFF JONATHAN S	Director	Buy	P	4.50	8,888,888	39,999,996	22,907,488	14 M to 22.9 M (+63.41 %)
Aug 03 2009	ISPH	INSPIRE PHARMACEUT ...	YERXA BENJAMIN R	EVP & Chf, Research ...	Sell	S	4.61	100	461	70,257	70.4 K to 70.3 K (-0.14 %)
Aug 03 2009	ISPH	INSPIRE PHARMACEUT ...	YERXA BENJAMIN R	EVP & Chf, Research ...	Sell	S	4.68	100	468	70,357	70.5 K to 70.4 K (-0.14 %)
Aug 03 2009	ISPH	INSPIRE PHARMACEUT ...	YERXA BENJAMIN R	EVP & Chf, Research ...	Sell	S	4.71	200	942	70,457	70.7 K to 70.5 K (-0.28 %)
Aug 03 2009	ISPH	INSPIRE PHARMACEUT ...	YERXA BENJAMIN R	EVP & Chf, Research ...	Sell	S	4.72	300	1,416	70,657	71 K to 70.7 K (-0.42 %)
Aug 03 2009	ISPH	INSPIRE PHARMACEUT ...	YERXA BENJAMIN R	EVP & Chf, Research ...	Sell	S	4.79	100	479	70,957	71.1 K to 71 K (-0.14 %)
Aug 03 2009	ISPH	INSPIRE PHARMACEUT ...	YERXA BENJAMIN R	EVP & Chf, Research ...	Sell	S	4.82	478	2,304	71,057	71.5 K to 71.1 K (-0.67 %)
Aug 03 2009	ISPH	INSPIRE PHARMACEUT ...	YERXA BENJAMIN R	EVP & Chf, Research ...	Sell	S	4.84	22	106	71,535	71.6 K to 71.5 K (-0.03 %)
Aug 03 2009	ISPH	INSPIRE PHARMACEUT ...	YERXA BENJAMIN R	EVP & Chf, Research ...	Sell	S	4.88	200	976	71,557	71.8 K to 71.6 K (-0.28 %)
Aug 03 2009	ISPH	INSPIRE PHARMACEUT ...	YERXA BENJAMIN R	EVP & Chf, Research ...	Sell	S	4.94	200	988	71,757	72 K to 71.8 K (-0.28 %)
Aug 03 2009	ISPH	INSPIRE PHARMACEUT ...	YERXA BENJAMIN R	EVP & Chf, Research ...	Sell	S	4.96	100	496	71,957	72.1 K to 72 K (-0.14 %)
Aug 03 2009	ISPH	INSPIRE PHARMACEUT ...	YERXA BENJAMIN R	EVP & Chf, Research ...	Sell	S	5.00	100	500	72,057	72.2 K to 72.1 K (-0.14 %)
Aug 03 2009	ISPH	INSPIRE PHARMACEUT ...	YERXA BENJAMIN R	EVP & Chf, Research ...	Sell	S	5.01	100	501	72,157	72.3 K to 72.2 K (-0.14 %)
Jul 02 2009	ISPH	INSPIRE PHARMACEUT ...	YERXA BENJAMIN R	EVP & Chf, Research ...	Sell	S	5.53	100	553	72,257	72.4 K to 72.3 K (-0.14 %)
Jul 02 2009	ISPH	INSPIRE PHARMACEUT ...	YERXA BENJAMIN R	EVP & Chf, Research ...	Sell	S	5.57	300	1,671	72,357	72.7 K to 72.4 K (-0.41 %)
Jul 02 2009	ISPH	INSPIRE PHARMACEUT ...	YERXA BENJAMIN R	EVP & Chf, Research ...	Sell	S	5.58	200	1,116	72,657	72.9 K to 72.7 K (-0.27 %)
Jul 02 2009	ISPH	INSPIRE PHARMACEUT ...	YERXA BENJAMIN R	EVP & Chf, Research ...	Sell	S	5.59	100	559	72,857	73 K to 72.9 K (-0.14 %)
Jul 02 2009	ISPH	INSPIRE PHARMACEUT ...	YERXA BENJAMIN R	EVP & Chf, Research ...	Sell	S	5.62	100	562	72,957	73.1 K to 73 K (-0.14 %)
Jul 02 2009	ISPH	INSPIRE PHARMACEUT ...	YERXA BENJAMIN R	EVP & Chf, Research ...	Sell	S	5.63	200	1,126	73,057	73.3 K to 73.1 K (-0.27 %)
Jul 02 2009	ISPH	INSPIRE PHARMACEUT ...	YERXA BENJAMIN R	EVP & Chf, Research ...	Sell	S	5.65	800	4,520	73,257	74.1 K to 73.3 K (-1.08 %)
Jul 02 2009	ISPH	INSPIRE PHARMACEUT ...	YERXA BENJAMIN R	EVP & Chf, Research ...	Sell	S	5.67	200	1,134	74,057	74.3 K to 74.1 K (-0.27 %)
Jun 16 2009	ISPH	INSPIRE PHARMACEUT ...	YERXA BENJAMIN R	EVP & Chf, Research ...	Sell	S	4.94	500	2,470	74,257	74.8 K to 74.3 K (-0.67 %)
Jun 16 2009	ISPH	INSPIRE PHARMACEUT ...	YERXA BENJAMIN R	EVP & Chf, Research ...	Sell	S	4.97	2,625	13,046	74,757	77.4 K to 74.8 K (-3.39 %)
Jun 16 2009	ISPH	INSPIRE PHARMACEUT ...	YERXA BENJAMIN R	EVP & Chf, Research ...	Sell	S	4.98	1,400	6,972	77,382	78.8 K to 77.4 K (-1.78 %)
Jun 16 2009	ISPH	INSPIRE PHARMACEUT ...	YERXA BENJAMIN R	EVP & Chf, Research ...	Sell	S	4.99	200	998	78,782	79 K to 78.8 K (-0.25 %)
Jun 16 2009	ISPH	INSPIRE PHARMACEUT ...	YERXA BENJAMIN R	EVP & Chf, Research ...	Sell	S	5.00	500	2,500	78,982	79.5 K to 79 K (-0.63 %)
Jun 16 2009	ISPH	INSPIRE PHARMACEUT ...	YERXA BENJAMIN R	EVP & Chf, Research ...	Sell	S	5.01	400	2,004	79,482	79.9 K to 79.5 K (-0.50 %)
Jun 16 2009	ISPH	INSPIRE PHARMACEUT ...	YERXA BENJAMIN R	EVP & Chf, Research ...	Sell	S	5.07	300	1,521	79,882	80.2 K to 79.9 K (-0.37 %)
Jun 16 2009	ISPH	INSPIRE PHARMACEUT ...	YERXA BENJAMIN R	EVP & Chf, Research ...	Sell	S	5.15	100	515	80,182	80.3 K to 80.2 K (-0.12 %)
Jun 16 2009	ISPH	INSPIRE PHARMACEUT ...	YERXA BENJAMIN R	EVP & Chf, Research ...	Sell	S	5.16	100	516	80,282	80.4 K to 80.3 K (-0.12 %)
Jun 09 2009	ISPH	INSPIRE PHARMACEUT ...	LEFF JONATHAN S	Director	Option Exercise	A	5.05	30,000	151,500	30,000
Jun 09 2009	ISPH	INSPIRE PHARMACEUT ...	Kent Richard S	Director	Option Exercise	A	5.05	30,000	151,500	30,000
Jun 09 2009	ISPH	INSPIRE PHARMACEUT ...	HOLMER ALAN F	Director	Option Exercise	A	5.05	30,000	151,500	30,000
Jun 09 2009	ISPH	INSPIRE PHARMACEUT ...	Hutson Nancy J	Director	Option Exercise	A	5.05	30,000	151,500	30,000
Jun 09 2009	ISPH	INSPIRE PHARMACEUT ...	FREY KIP	Director	Option Exercise	A	5.05	30,000	151,500	30,000
May 18 2009	ISPH	INSPIRE PHARMACEUT ...	SCHACHLE JOSEPH K	EVP, Chief Commerci ...	Option Exercise	A	3.84	10,000	38,400	10,000
May 18 2009	ISPH	INSPIRE PHARMACEUT ...	SHAFFER CHRISTY L	President & CEO	Option Exercise	A	3.84	29,500	113,280	29,500
Jun 09 2009	ISPH	INSPIRE PHARMACEUT ...	LEE KENNETH B JR	Director	Option Exercise	A	5.05	10,000	50,500	10,000
Jun 09 2009	ISPH	INSPIRE PHARMACEUT ...	LEE KENNETH B JR	Director	Option Exercise	A	5.05	30,000	151,500	30,000
May 18 2009	ISPH	INSPIRE PHARMACEUT ...	Brazzell Romulus K	EVP & Head, Ophthal ...	Option Exercise	A	3.84	13,250	50,880	13,250
May 18 2009	ISPH	INSPIRE PHARMACEUT ...	STAAB THOMAS R II	CFO & Treasurer	Option Exercise	A	3.84	13,250	50,880	13,250
May 18 2009	ISPH	INSPIRE PHARMACEUT ...	Spagnardi Joseph M	Senior VP, GC & Sec ...	Option Exercise	A	3.84	10,250	39,360	10,250
May 18 2009	ISPH	INSPIRE PHARMACEUT ...	YERXA BENJAMIN R	EVP & Chf, Research ...	Option Exercise	A	3.84	12,000	46,080	12,000
Mar 20 2009	ISPH	INSPIRE PHARMACEUT ...	SCHACHLE JOSEPH K	EVP, Chief Commerci ...	Option Exercise	A	3.79	10,000	37,900	10,000
Mar 20 2009	ISPH	INSPIRE PHARMACEUT ...	YERXA BENJAMIN R	EVP & Chf, Research ...	Option Exercise	A	3.79	12,000	45,480	12,000
Mar 20 2009	ISPH	INSPIRE PHARMACEUT ...	STAAB THOMAS R II	CFO & Treasurer	Option Exercise	A	3.79	13,250	50,218	13,250
Mar 20 2009	ISPH	INSPIRE PHARMACEUT ...	Spagnardi Joseph M	Senior VP, GC & Sec ...	Option Exercise	A	3.79	10,250	38,848	10,250
Mar 20 2009	ISPH	INSPIRE PHARMACEUT ...	Brazzell Romulus K	EVP & Head, Ophthal ...	Option Exercise	A	3.79	13,250	50,218	13,250
Mar 20 2009	ISPH	INSPIRE PHARMACEUT ...	SHAFFER CHRISTY L	President & CEO	Option Exercise	A	3.79	29,500	111,805	29,500
Feb 10 2009	ISPH	INSPIRE PHARMACEUT ...	HOLMER ALAN F	Director	Option Exercise	A	3.85	7,500	28,875	7,500
Nov 06 2008	ISPH	INSPIRE PHARMACEUT ...	LEE KENNETH B JR	Director	Buy	P	3.88	1,600	6,208	2,400	800 to 2.4 K (+200.00 %)
Nov 06 2008	ISPH	INSPIRE PHARMACEUT ...	LEE KENNETH B JR	Director	Buy	P	3.88	400	1,551	800	400 to 800 (+100.00 %)
Nov 12 2008	ISPH	INSPIRE PHARMACEUT ...	FREY KIP	Director	Buy	P	3.40	2,000	6,800	2,000	0 to 2 K
Nov 06 2008	ISPH	INSPIRE PHARMACEUT ...	SHAFFER CHRISTY L	President & CEO	Option Exercise	A	3.78	29,500	111,510	29,500
Nov 06 2008	ISPH	INSPIRE PHARMACEUT ...	YERXA BENJAMIN R	EVP & Chf, Research ...	Option Exercise	M	0.42	9,131	3,835	0
Nov 06 2008	ISPH	INSPIRE PHARMACEUT ...	YERXA BENJAMIN R	EVP & Chf, Research ...	Option Exercise	A	3.78	13,250	50,085	13,250
Nov 06 2008	ISPH	INSPIRE PHARMACEUT ...	YERXA BENJAMIN R	EVP & Chf, Research ...	Buy	M	0.42	9,131	3,835	80,382	71.3 K to 80.4 K (+12.82 %)
Nov 06 2008	ISPH	INSPIRE PHARMACEUT ...	SCHACHLE JOSEPH K	EVP, Chief Commerci ...	Option Exercise	A	3.78	13,250	50,085	13,250
Nov 06 2008	ISPH	INSPIRE PHARMACEUT ...	STAAB THOMAS R II	CFO & Treasurer	Option Exercise	A	3.78	13,250	50,085	13,250
Nov 06 2008	ISPH	INSPIRE PHARMACEUT ...	Brazzell Romulus K	Sr. VP, Ophthalmic ...	Option Exercise	A	3.78	10,250	38,745	10,250
Nov 06 2008	ISPH	INSPIRE PHARMACEUT ...	Spagnardi Joseph M	Senior VP, GC & Sec ...	Option Exercise	A	3.78	10,250	38,745	10,250
Aug 18 2008	ISPH	INSPIRE PHARMACEUT ...	SHAFFER CHRISTY L	President & CEO	Option Exercise	A	4.44	29,500	130,980	29,500
Aug 18 2008	ISPH	INSPIRE PHARMACEUT ...	YERXA BENJAMIN R	Chf Sci Off & EVP S ...	Option Exercise	A	4.44	13,250	58,830	13,250
Aug 18 2008	ISPH	INSPIRE PHARMACEUT ...	SCHACHLE JOSEPH K	EVP, Chief Commerci ...	Option Exercise	A	4.44	13,250	58,830	13,250
Aug 18 2008	ISPH	INSPIRE PHARMACEUT ...	STAAB THOMAS R II	CFO & Treasurer	Option Exercise	A	4.44	13,250	58,830	13,250
Aug 18 2008	ISPH	INSPIRE PHARMACEUT ...	Brazzell Romulus K	Sr. VP, Ophthalmic ...	Option Exercise	A	4.44	10,250	45,510	10,250
Aug 18 2008	ISPH	INSPIRE PHARMACEUT ...	Spagnardi Joseph M	Senior VP, GC & Sec ...	Option Exercise	A	4.44	10,250	45,510	10,250
Jul 23 2008	ISPH	INSPIRE PHARMACEUT ...	KELLERMAN DONALD J	Senior VP, Developm ...	Sell	D	0.00	12,000	0	8,000	20 K to 8 K (-60.00 %)
Jun 12 2008	ISPH	INSPIRE PHARMACEUT ...	LEFF JONATHAN S	Director	Option Exercise	A	5.00	30,000	150,000	30,000
Jun 12 2008	ISPH	INSPIRE PHARMACEUT ...	Hutson Nancy J	Director	Option Exercise	A	5.00	30,000	150,000	30,000
Jun 12 2008	ISPH	INSPIRE PHARMACEUT ...	FREY KIP	Director	Option Exercise	A	5.00	30,000	150,000	30,000
Jun 12 2008	ISPH	INSPIRE PHARMACEUT ...	Kent Richard S	Director	Option Exercise	A	5.00	30,000	150,000	30,000
Jun 12 2008	ISPH	INSPIRE PHARMACEUT ...	LEE KENNETH B JR	Director	Option Exercise	A	5.00	10,000	50,000	10,000
Jun 12 2008	ISPH	INSPIRE PHARMACEUT ...	LEE KENNETH B JR	Director	Option Exercise	A	5.00	30,000	150,000	30,000
May 19 2008	ISPH	INSPIRE PHARMACEUT ...	YERXA BENJAMIN R	Chf Sci Off & EVP S ...	Option Exercise	A	3.49	14,000	48,860	14,000
May 19 2008	ISPH	INSPIRE PHARMACEUT ...	SHAFFER CHRISTY L	President & CEO	Option Exercise	A	3.49	29,500	102,955	29,500

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