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General | Insiders | Insider Transactions | Monthly Overview | Weekly Overview

Overview of all insider trading transactions in INSPIRE PHARMACEUTICALS INC. Get notifications about new insider transactions in INSPIRE PHARMACEUTICALS INC for free.

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Date	Ticker	Company	Owner	Relationship	Transaction	Code	Cost ($)	Shares	Transaction Value ($)	Total Shares	% Holdings
Jan 23 2006	ISPH	INSPIRE PHARMACEUT ...	Brazzell Romulus K	Sr. VP, Ophthalmic ...	Option Exercise	A	5.25	25,000	131,250	25,000
Jan 23 2006	ISPH	INSPIRE PHARMACEUT ...	Pea Barry G	Exec. VP, Corp. Dev ...	Option Exercise	A	5.25	30,000	157,500	30,000
Jan 23 2006	ISPH	INSPIRE PHARMACEUT ...	BENNETT MARY B	Exec. VP, Operation ...	Option Exercise	A	5.25	30,000	157,500	30,000
Jan 23 2006	ISPH	INSPIRE PHARMACEUT ...	SCHACHLE JOSEPH K	Sr. VP, Marketing & ...	Option Exercise	A	5.25	30,000	157,500	30,000
Jan 23 2006	ISPH	INSPIRE PHARMACEUT ...	YERXA BENJAMIN R	Chief, Sci. Op. & A ...	Option Exercise	A	5.25	20,000	105,000	20,000
Jan 23 2006	ISPH	INSPIRE PHARMACEUT ...	STAAB THOMAS R II	CFO & Treasurer	Option Exercise	A	5.25	15,000	78,750	15,000
Jan 23 2006	ISPH	INSPIRE PHARMACEUT ...	EVANS RICHARD M	VP, Pharmaceutical ...	Option Exercise	A	5.25	10,000	52,500	10,000
Jan 23 2006	ISPH	INSPIRE PHARMACEUT ...	KELLERMAN DONALD J	Senior VP, Developm ...	Option Exercise	A	5.25	12,500	65,625	12,500
Jan 23 2006	ISPH	INSPIRE PHARMACEUT ...	SHAFFER CHRISTY L	President & CEO	Option Exercise	A	5.25	45,000	236,250	45,000
Jul 14 2005	ISPH	INSPIRE PHARMACEUT ...	SHAFFER CHRISTY L	President & CEO	Option Exercise	A	9.42	90,000	847,800	90,000
Jul 14 2005	ISPH	INSPIRE PHARMACEUT ...	Brazzell Romulus K	Sr. VP of Ophthalmi ...	Option Exercise	A	9.42	40,000	376,800	40,000
Jul 14 2005	ISPH	INSPIRE PHARMACEUT ...	Pea Barry G	Exec. VP of Corp. D ...	Option Exercise	A	9.42	65,000	612,300	65,000
Jul 14 2005	ISPH	INSPIRE PHARMACEUT ...	SCHACHLE JOSEPH K	Sr. VP, Marketing & ...	Option Exercise	A	9.42	30,000	282,600	30,000
Jul 14 2005	ISPH	INSPIRE PHARMACEUT ...	BENNETT MARY B	Exec. VP, Operation ...	Option Exercise	A	9.42	60,000	565,200	60,000
Jul 14 2005	ISPH	INSPIRE PHARMACEUT ...	YERXA BENJAMIN R	Senior Vice Pres., ...	Option Exercise	A	9.42	29,250	275,535	29,250
Jul 14 2005	ISPH	INSPIRE PHARMACEUT ...	STAAB THOMAS R II	CFO & Treasurer	Option Exercise	A	9.42	28,500	268,470	28,500
Jul 14 2005	ISPH	INSPIRE PHARMACEUT ...	KELLERMAN DONALD J	Senior VP, Developm ...	Option Exercise	A	9.42	28,500	268,470	28,500
Jul 14 2005	ISPH	INSPIRE PHARMACEUT ...	EVANS RICHARD M	VP, Pharmaceutical ...	Option Exercise	A	9.42	19,500	183,690	19,500
Jun 13 2005	ISPH	INSPIRE PHARMACEUT ...	FREY KIP	Director	Option Exercise	A	6.92	2,000	13,840	2,000
Jun 13 2005	ISPH	INSPIRE PHARMACEUT ...	FREY KIP	Director	Option Exercise	A	6.92	4,000	27,680	4,000
Jun 13 2005	ISPH	INSPIRE PHARMACEUT ...	FREY KIP	Director	Option Exercise	A	6.92	20,000	138,400	20,000
Jun 13 2005	ISPH	INSPIRE PHARMACEUT ...	LEE KENNETH B JR	Director	Option Exercise	A	6.92	4,000	27,680	4,000
Jun 13 2005	ISPH	INSPIRE PHARMACEUT ...	LEE KENNETH B JR	Director	Option Exercise	A	6.92	2,000	13,840	2,000
Jun 13 2005	ISPH	INSPIRE PHARMACEUT ...	LEE KENNETH B JR	Director	Option Exercise	A	6.92	4,000	27,680	4,000
Jun 13 2005	ISPH	INSPIRE PHARMACEUT ...	LEE KENNETH B JR	Director	Option Exercise	A	6.92	20,000	138,400	20,000
Jun 13 2005	ISPH	INSPIRE PHARMACEUT ...	Kent Richard S	Director	Option Exercise	A	6.92	2,000	13,840	2,000
Jun 13 2005	ISPH	INSPIRE PHARMACEUT ...	Kent Richard S	Director	Option Exercise	A	6.92	2,000	13,840	2,000
Jun 13 2005	ISPH	INSPIRE PHARMACEUT ...	Kent Richard S	Director	Option Exercise	A	6.92	10,000	69,200	10,000
Jun 13 2005	ISPH	INSPIRE PHARMACEUT ...	RINGO WILLIAM R	Director	Option Exercise	A	6.92	4,000	27,680	4,000
Jun 13 2005	ISPH	INSPIRE PHARMACEUT ...	RINGO WILLIAM R	Director	Option Exercise	A	6.92	10,000	69,200	10,000
Jun 13 2005	ISPH	INSPIRE PHARMACEUT ...	HOLMER ALAN F	Director	Option Exercise	A	6.92	2,000	13,840	2,000
Jun 13 2005	ISPH	INSPIRE PHARMACEUT ...	HOLMER ALAN F	Director	Option Exercise	A	6.92	2,000	13,840	2,000
Jun 13 2005	ISPH	INSPIRE PHARMACEUT ...	HOLMER ALAN F	Director	Option Exercise	A	6.92	10,000	69,200	10,000
Mar 02 2005	ISPH	INSPIRE PHARMACEUT ...	MOSSINGHOFF GREGORY J	President	Option Exercise	M	0.84	71,428	60,000	0
Mar 02 2005	ISPH	INSPIRE PHARMACEUT ...	MOSSINGHOFF GREGORY J	President	Buy	M	0.84	71,428	60,000	107,855	36.4 K to 107.9 K (+196.09 %)
Feb 28 2005	ISPH	INSPIRE PHARMACEUT ...	SHAFFER CHRISTY L	Chief Executive Off ...	Option Exercise	M	0.21	120,713	25,350	0
Feb 28 2005	ISPH	INSPIRE PHARMACEUT ...	SHAFFER CHRISTY L	Chief Executive Off ...	Buy	M	0.21	120,713	25,350	222,212	101.5 K to 222.2 K (+118.93 %)
Feb 22 2005	ISPH	INSPIRE PHARMACEUT ...	LEE KENNETH B JR	Director	Option Exercise	A	8.43	667	5,623	667
Feb 22 2005	ISPH	INSPIRE PHARMACEUT ...	LEE KENNETH B JR	Director	Option Exercise	A	8.43	1,334	11,246	1,334
Feb 04 2005	ISPH	INSPIRE PHARMACEUT ...	KELLERMAN DONALD J	Senior VP, Developm ...	Option Exercise	M	0.84	2,000	1,680	34,428
Feb 04 2005	ISPH	INSPIRE PHARMACEUT ...	KELLERMAN DONALD J	Senior VP, Developm ...	Sell	S	14.83	2,000	29,659	0	2 K to 0 (-100.00 %)
Feb 04 2005	ISPH	INSPIRE PHARMACEUT ...	KELLERMAN DONALD J	Senior VP, Developm ...	Buy	M	0.84	2,000	1,680	2,000	0 to 2 K
Jan 04 2005	ISPH	INSPIRE PHARMACEUT ...	KELLERMAN DONALD J	Senior VP, Developm ...	Option Exercise	M	0.84	2,000	1,680	36,428
Jan 04 2005	ISPH	INSPIRE PHARMACEUT ...	KELLERMAN DONALD J	Senior VP, Developm ...	Sell	S	16.27	2,000	32,540	0	2 K to 0 (-100.00 %)
Jan 04 2005	ISPH	INSPIRE PHARMACEUT ...	KELLERMAN DONALD J	Senior VP, Developm ...	Buy	M	0.84	2,000	1,680	2,000	0 to 2 K
Dec 02 2004	ISPH	INSPIRE PHARMACEUT ...	SHAFFER CHRISTY L	Chief Executive Off ...	Option Exercise	M	0.21	25,000	5,250	120,713
Dec 02 2004	ISPH	INSPIRE PHARMACEUT ...	SHAFFER CHRISTY L	Chief Executive Off ...	Buy	M	0.21	25,000	5,250	106,499	81.5 K to 106.5 K (+30.68 %)
Dec 02 2004	ISPH	INSPIRE PHARMACEUT ...	SHAFFER CHRISTY L	Chief Executive Off ...	Gift	G	0.00	12,000	0	81,499	93.5 K to 81.5 K (-12.83 %)
Dec 03 2004	ISPH	INSPIRE PHARMACEUT ...	KELLERMAN DONALD J	Senior VP, Developm ...	Option Exercise	M	0.84	2,000	1,680	38,428
Dec 03 2004	ISPH	INSPIRE PHARMACEUT ...	KELLERMAN DONALD J	Senior VP, Developm ...	Sell	S	18.28	2,000	36,560	0	2 K to 0 (-100.00 %)
Dec 03 2004	ISPH	INSPIRE PHARMACEUT ...	KELLERMAN DONALD J	Senior VP, Developm ...	Buy	M	0.84	2,000	1,680	2,000	0 to 2 K
Nov 23 2004	ISPH	INSPIRE PHARMACEUT ...	NOVACK GARY D	Director	Option Exercise	M	4.20	5,728	24,058	0
Nov 23 2004	ISPH	INSPIRE PHARMACEUT ...	NOVACK GARY D	Director	Sell	S	17.49	300	5,247	6,453	6.8 K to 6.5 K (-4.44 %)
Nov 23 2004	ISPH	INSPIRE PHARMACEUT ...	NOVACK GARY D	Director	Sell	S	17.48	400	6,992	6,753	7.2 K to 6.8 K (-5.59 %)
Nov 23 2004	ISPH	INSPIRE PHARMACEUT ...	NOVACK GARY D	Director	Sell	S	17.47	1,000	17,470	7,153	8.2 K to 7.2 K (-12.27 %)
Nov 23 2004	ISPH	INSPIRE PHARMACEUT ...	NOVACK GARY D	Director	Sell	S	17.45	4,000	69,800	8,153	12.2 K to 8.2 K (-32.91 %)
Nov 23 2004	ISPH	INSPIRE PHARMACEUT ...	NOVACK GARY D	Director	Buy	M	4.20	5,728	24,058	12,153	6.4 K to 12.2 K (+89.15 %)
Dec 01 2004	ISPH	INSPIRE PHARMACEUT ...	MOSSINGHOFF GREGORY J	President	Sell	S	17.90	13,000	232,721	36,427	49.4 K to 36.4 K (-26.30 %)
Dec 01 2004	ISPH	INSPIRE PHARMACEUT ...	MOSSINGHOFF GREGORY J	President	Sell	S	17.96	10,000	179,563	49,427	59.4 K to 49.4 K (-16.83 %)
Dec 01 2004	ISPH	INSPIRE PHARMACEUT ...	MOSSINGHOFF GREGORY J	President	Sell	S	18.00	12,000	216,000	59,427	71.4 K to 59.4 K (-16.80 %)
Nov 03 2004	ISPH	INSPIRE PHARMACEUT ...	KELLERMAN DONALD J	Senior VP, Developm ...	Option Exercise	M	0.84	2,000	1,680	40,428
Nov 03 2004	ISPH	INSPIRE PHARMACEUT ...	KELLERMAN DONALD J	Senior VP, Developm ...	Sell	S	15.64	2,000	31,272	0	2 K to 0 (-100.00 %)
Nov 03 2004	ISPH	INSPIRE PHARMACEUT ...	KELLERMAN DONALD J	Senior VP, Developm ...	Buy	M	0.84	2,000	1,680	2,000	0 to 2 K
Nov 17 2004	ISPH	INSPIRE PHARMACEUT ...	SHAFFER CHRISTY L	Chief Executive Off ...	Sell	S	17.92	10,000	179,195	93,499	103.5 K to 93.5 K (-9.66 %)
Oct 07 2004	ISPH	INSPIRE PHARMACEUT ...	KELLERMAN DONALD J	Senior VP, Developm ...	Option Exercise	M	0.84	2,000	1,680	42,428
Oct 07 2004	ISPH	INSPIRE PHARMACEUT ...	KELLERMAN DONALD J	Senior VP, Developm ...	Sell	S	15.68	2,000	31,369	0	2 K to 0 (-100.00 %)
Oct 07 2004	ISPH	INSPIRE PHARMACEUT ...	KELLERMAN DONALD J	Senior VP, Developm ...	Buy	M	0.84	2,000	1,680	2,000	0 to 2 K
Oct 13 2004	ISPH	INSPIRE PHARMACEUT ...	Pea Barry G	Exec. VP of Corp. D ...	Option Exercise	A	15.78	60,000	946,800	60,000
Sep 29 2004	ISPH	INSPIRE PHARMACEUT ...	SHAFFER CHRISTY L	Chief Executive Off ...	Option Exercise	A	15.65	35,000	547,750	35,000
Sep 29 2004	ISPH	INSPIRE PHARMACEUT ...	KELLERMAN DONALD J	Senior VP, Developm ...	Option Exercise	A	15.65	9,800	153,370	9,800
Sep 29 2004	ISPH	INSPIRE PHARMACEUT ...	YERXA BENJAMIN R	Senior Vice Pres., ...	Option Exercise	A	15.65	9,700	151,805	9,700
Sep 29 2004	ISPH	INSPIRE PHARMACEUT ...	BENNETT MARY B	Senior VP, Operatio ...	Option Exercise	A	15.65	10,000	156,500	10,000
Sep 29 2004	ISPH	INSPIRE PHARMACEUT ...	STAAB THOMAS R II	Chief Financial Off ...	Option Exercise	A	15.65	9,300	145,545	9,300
Sep 29 2004	ISPH	INSPIRE PHARMACEUT ...	EVANS RICHARD M	VP, Pharmaceutical ...	Option Exercise	A	15.65	9,300	145,545	9,300
Sep 29 2004	ISPH	INSPIRE PHARMACEUT ...	SCHACHLE JOSEPH K	Sr. VP, Sales & Mar ...	Option Exercise	A	15.65	10,000	156,500	10,000
Sep 29 2004	ISPH	INSPIRE PHARMACEUT ...	SCHACHLE JOSEPH K	Sr. VP, Sales & Mar ...	Option Exercise	A	15.65	10,000	156,500	10,000
Sep 14 2004	ISPH	INSPIRE PHARMACEUT ...	Kent Richard S	Director	Option Exercise	A	15.83	1,500	23,745	1,500
Sep 09 2004	ISPH	INSPIRE PHARMACEUT ...	KELLERMAN DONALD J	Senior VP, Developm ...	Option Exercise	M	0.84	2,000	1,680	44,428
Sep 09 2004	ISPH	INSPIRE PHARMACEUT ...	KELLERMAN DONALD J	Senior VP, Developm ...	Sell	S	15.18	2,000	30,355	0	2 K to 0 (-100.00 %)
Sep 09 2004	ISPH	INSPIRE PHARMACEUT ...	KELLERMAN DONALD J	Senior VP, Developm ...	Buy	M	0.84	2,000	1,680	2,000	0 to 2 K
Aug 04 2004	ISPH	INSPIRE PHARMACEUT ...	KELLERMAN DONALD J	Senior VP, Developm ...	Sell	S	12.95	2,000	25,893	0	2 K to 0 (-100.00 %)
Aug 04 2004	ISPH	INSPIRE PHARMACEUT ...	KELLERMAN DONALD J	Senior VP, Developm ...	Sell	S	12.95	2,000	25,893	0	2 K to 0 (-100.00 %)
Aug 04 2004	ISPH	INSPIRE PHARMACEUT ...	SHAFFER CHRISTY L	Chief Executive Off ...	Sell	S	12.75	2,000	25,500	103,499	105.5 K to 103.5 K (-1.90 %)
Aug 03 2004	ISPH	INSPIRE PHARMACEUT ...	Brazzell Kim	Sr. VP of Ophthalmi ...	Option Exercise	A	12.91	40,000	516,400	40,000
Jul 07 2004	ISPH	INSPIRE PHARMACEUT ...	SHAFFER CHRISTY L	Chief Executive Off ...	Sell	S	16.32	2,000	32,635	105,499	107.5 K to 105.5 K (-1.86 %)
Jul 07 2004	ISPH	INSPIRE PHARMACEUT ...	SHAFFER CHRISTY L	Chief Executive Off ...	Sell	S	16.32	2,000	32,635	105,499	107.5 K to 105.5 K (-1.86 %)
Jul 07 2004	ISPH	INSPIRE PHARMACEUT ...	KELLERMAN DONALD J	Senior VP, Developm ...	Sell	S	16.34	2,000	32,681	2,000	4 K to 2 K (-50.00 %)
Jun 14 2004	ISPH	INSPIRE PHARMACEUT ...	FREY KIP	Director	Option Exercise	A	16.76	2,000	33,520	2,000
Jun 14 2004	ISPH	INSPIRE PHARMACEUT ...	FREY KIP	Director	Option Exercise	A	16.76	4,000	67,040	4,000
Jun 14 2004	ISPH	INSPIRE PHARMACEUT ...	FREY KIP	Director	Option Exercise	A	16.76	10,000	167,600	10,000
Jun 14 2004	ISPH	INSPIRE PHARMACEUT ...	THOMPSON W LEIGH MD PHD	Director	Option Exercise	A	16.76	4,000	67,040	4,000
Jun 14 2004	ISPH	INSPIRE PHARMACEUT ...	THOMPSON W LEIGH MD PHD	Director	Option Exercise	A	16.76	2,000	33,520	2,000
Jun 14 2004	ISPH	INSPIRE PHARMACEUT ...	THOMPSON W LEIGH MD PHD	Director	Option Exercise	A	16.76	2,000	33,520	2,000
Jun 14 2004	ISPH	INSPIRE PHARMACEUT ...	THOMPSON W LEIGH MD PHD	Director	Option Exercise	A	16.76	10,000	167,600	10,000
Jun 14 2004	ISPH	INSPIRE PHARMACEUT ...	THOMPSON W LEIGH MD PHD	Director	Option Exercise	A	16.76	4,000	67,040	4,000
Jun 14 2004	ISPH	INSPIRE PHARMACEUT ...	THOMPSON W LEIGH MD PHD	Director	Option Exercise	A	16.76	2,000	33,520	2,000
Jun 14 2004	ISPH	INSPIRE PHARMACEUT ...	THOMPSON W LEIGH MD PHD	Director	Option Exercise	A	16.76	2,000	33,520	2,000
Jun 14 2004	ISPH	INSPIRE PHARMACEUT ...	THOMPSON W LEIGH MD PHD	Director	Option Exercise	A	16.76	10,000	167,600	10,000
Jun 14 2004	ISPH	INSPIRE PHARMACEUT ...	Kent Richard S	Director	Option Exercise	A	16.76	2,000	33,520	2,000
Jun 14 2004	ISPH	INSPIRE PHARMACEUT ...	Kent Richard S	Director	Option Exercise	A	16.76	20,000	335,200	20,000
Jun 14 2004	ISPH	INSPIRE PHARMACEUT ...	LEE KENNETH B JR	Director	Option Exercise	A	16.76	2,000	33,520	2,000
Jun 14 2004	ISPH	INSPIRE PHARMACEUT ...	LEE KENNETH B JR	Director	Option Exercise	A	16.76	2,000	33,520	2,000
Jun 14 2004	ISPH	INSPIRE PHARMACEUT ...	LEE KENNETH B JR	Director	Option Exercise	A	16.76	4,000	67,040	4,000
Jun 14 2004	ISPH	INSPIRE PHARMACEUT ...	LEE KENNETH B JR	Director	Option Exercise	A	16.76	10,000	167,600	10,000
Jun 14 2004	ISPH	INSPIRE PHARMACEUT ...	NOVACK GARY D	Director	Option Exercise	A	16.76	10,000	167,600	10,000
Jun 14 2004	ISPH	INSPIRE PHARMACEUT ...	NOVACK GARY D	Director	Option Exercise	A	16.76	10,000	167,600	10,000
Jun 14 2004	ISPH	INSPIRE PHARMACEUT ...	RINGO WILLIAM R	Director	Option Exercise	A	16.76	2,000	33,520	2,000
Jun 14 2004	ISPH	INSPIRE PHARMACEUT ...	RINGO WILLIAM R	Director	Option Exercise	A	16.76	4,000	67,040	4,000
Jun 14 2004	ISPH	INSPIRE PHARMACEUT ...	RINGO WILLIAM R	Director	Option Exercise	A	16.76	10,000	167,600	10,000
Jun 02 2004	ISPH	INSPIRE PHARMACEUT ...	KELLERMAN DONALD J	Senior VP, Developm ...	Sell	S	17.12	2,000	34,232	4,000	6 K to 4 K (-33.33 %)
Jun 02 2004	ISPH	INSPIRE PHARMACEUT ...	SHAFFER CHRISTY L	Chief Executive Off ...	Sell	S	17.14	2,000	34,282	107,499	109.5 K to 107.5 K (-1.83 %)
Jun 02 2004	ISPH	INSPIRE PHARMACEUT ...	SHAFFER CHRISTY L	Chief Executive Off ...	Sell	S	17.14	2,000	34,282	107,499	109.5 K to 107.5 K (-1.83 %)
May 05 2004	ISPH	INSPIRE PHARMACEUT ...	BOUCHER RICHARD		Sell	S	16.66	6,961	115,970	340,923	347.9 K to 340.9 K (-2.00 %)
May 05 2004	ISPH	INSPIRE PHARMACEUT ...	BOUCHER RICHARD		Sell	S	16.66	1,039	17,310	347,884	348.9 K to 347.9 K (-0.30 %)
May 05 2004	ISPH	INSPIRE PHARMACEUT ...	SHAFFER CHRISTY L	Chief Executive Off ...	Sell	S	16.31	2,000	32,620	109,499	111.5 K to 109.5 K (-1.79 %)
May 05 2004	ISPH	INSPIRE PHARMACEUT ...	KELLERMAN DONALD J	Senior VP, Developm ...	Sell	S	16.31	2,000	32,620	6,000	8 K to 6 K (-25.00 %)
May 05 2004	ISPH	INSPIRE PHARMACEUT ...	KELLERMAN DONALD J	Senior VP, Developm ...	Sell	S	16.31	2,000	32,620	6,000	8 K to 6 K (-25.00 %)
Apr 08 2004	ISPH	INSPIRE PHARMACEUT ...	BOUCHER RICHARD		Sell	S	14.20	6,196	88,009	348,923	355.1 K to 348.9 K (-1.74 %)
Apr 07 2004	ISPH	INSPIRE PHARMACEUT ...	KELLERMAN DONALD J	Senior VP, Developm ...	Sell	S	13.64	2,000	27,277	8,000	10 K to 8 K (-20.00 %)
Apr 07 2004	ISPH	INSPIRE PHARMACEUT ...	SHAFFER CHRISTY L	Chief Executive Off ...	Sell	S	13.73	2,000	27,458	111,499	113.5 K to 111.5 K (-1.76 %)
Apr 07 2004	ISPH	INSPIRE PHARMACEUT ...	SHAFFER CHRISTY L	Chief Executive Off ...	Sell	S	13.73	2,000	27,458	111,499	113.5 K to 111.5 K (-1.76 %)
Mar 22 2004	ISPH	INSPIRE PHARMACEUT ...	KELLERMAN DONALD J	Senior VP, Developm ...	Sell	S	12.88	2,000	25,752	10,000	12 K to 10 K (-16.67 %)
Mar 17 2004	ISPH	INSPIRE PHARMACEUT ...	YERXA BENJAMIN R	Senior Vice Pres., ...	Option Exercise	A	12.80	9,500	121,600	9,500
Mar 17 2004	ISPH	INSPIRE PHARMACEUT ...	EVANS RICHARD M	VP, Pharmaceutical ...	Option Exercise	A	12.80	9,000	115,200	9,000
Mar 17 2004	ISPH	INSPIRE PHARMACEUT ...	SHAFFER CHRISTY L	Chief Executive Off ...	Option Exercise	A	12.80	35,000	448,000	35,000
Mar 17 2004	ISPH	INSPIRE PHARMACEUT ...	SCHACHLE JOSEPH K	Sr. VP, Sales & Mar ...	Option Exercise	A	12.80	10,000	128,000	10,000
Mar 17 2004	ISPH	INSPIRE PHARMACEUT ...	BENNETT MARY B	Senior VP, Operatio ...	Option Exercise	A	12.80	10,000	128,000	10,000
Mar 17 2004	ISPH	INSPIRE PHARMACEUT ...	KELLERMAN DONALD J	Senior VP, Developm ...	Option Exercise	A	12.80	9,500	121,600	9,500
Mar 17 2004	ISPH	INSPIRE PHARMACEUT ...	STAAB THOMAS R II	Chief Financial Off ...	Option Exercise	A	12.80	8,000	102,400	8,000
Mar 10 2004	ISPH	INSPIRE PHARMACEUT ...	BOUCHER RICHARD		Sell	S	15.02	10,000	150,200	355,119	365.1 K to 355.1 K (-2.74 %)
Mar 10 2004	ISPH	INSPIRE PHARMACEUT ...	BOUCHER RICHARD		Sell	S	14.84	5,334	79,134	365,119	370.5 K to 365.1 K (-1.44 %)
Mar 09 2004	ISPH	INSPIRE PHARMACEUT ...	BOUCHER RICHARD		Sell	S	14.12	10,000	141,205	370,453	380.5 K to 370.5 K (-2.63 %)
Mar 04 2004	ISPH	INSPIRE PHARMACEUT ...	SHAFFER CHRISTY L	Chief Executive Off ...	Option Exercise	M	0.21	25,000	5,250	145,713
Mar 04 2004	ISPH	INSPIRE PHARMACEUT ...	SHAFFER CHRISTY L	Chief Executive Off ...	Buy	M	0.21	25,000	5,250	113,499	88.5 K to 113.5 K (+28.25 %)
Mar 02 2004	ISPH	INSPIRE PHARMACEUT ...	SHAFFER CHRISTY L	Chief Executive Off ...	Sell	S	14.22	2,000	28,440	88,499	90.5 K to 88.5 K (-2.21 %)
Feb 03 2004	ISPH	INSPIRE PHARMACEUT ...	SHAFFER CHRISTY L	Chief Executive Off ...	Option Exercise	M	0.21	20,000	4,200	170,713
Feb 03 2004	ISPH	INSPIRE PHARMACEUT ...	SHAFFER CHRISTY L	Chief Executive Off ...	Sell	S	12.37	2,000	24,730	90,499	92.5 K to 90.5 K (-2.16 %)
Feb 03 2004	ISPH	INSPIRE PHARMACEUT ...	SHAFFER CHRISTY L	Chief Executive Off ...	Buy	M	0.21	20,000	4,200	92,499	72.5 K to 92.5 K (+27.59 %)

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