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General | Insiders | Insider Transactions | Monthly Overview | Weekly Overview

Overview of all insider trading transactions in INSPIRE PHARMACEUTICALS INC. Get notifications about new insider transactions in INSPIRE PHARMACEUTICALS INC for free.

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Date	Ticker	Company	Owner	Relationship	Transaction	Code	Cost ($)	Shares	Transaction Value ($)	Total Shares	% Holdings
May 19 2008	ISPH	INSPIRE PHARMACEUT ...	SCHACHLE JOSEPH K	EVP, Chief Commerci ...	Option Exercise	A	3.49	14,000	48,860	14,000
May 19 2008	ISPH	INSPIRE PHARMACEUT ...	KELLERMAN DONALD J	Senior VP, Developm ...	Option Exercise	A	3.49	11,000	38,390	11,000
May 19 2008	ISPH	INSPIRE PHARMACEUT ...	STAAB THOMAS R II	CFO & Treasurer	Option Exercise	A	3.49	11,250	39,263	11,250
May 19 2008	ISPH	INSPIRE PHARMACEUT ...	Brazzell Romulus K	Sr. VP, Ophthalmic ...	Option Exercise	A	3.49	10,250	35,773	10,250
May 19 2008	ISPH	INSPIRE PHARMACEUT ...	Spagnardi Joseph M	Senior VP, GC & Sec ...	Option Exercise	A	3.49	12,000	41,880	12,000
May 15 2008	ISPH	INSPIRE PHARMACEUT ...	YERXA BENJAMIN R	Chf Sci Off & EVP S ...	Option Exercise	M	0.42	8,130	3,415	9,131
May 15 2008	ISPH	INSPIRE PHARMACEUT ...	YERXA BENJAMIN R	Chf Sci Off & EVP S ...	Option Exercise	M	0.21	14,996	3,149	0
May 15 2008	ISPH	INSPIRE PHARMACEUT ...	YERXA BENJAMIN R	Chf Sci Off & EVP S ...	Buy	M	0.42	8,130	3,415	71,251	63.1 K to 71.3 K (+12.88 %)
May 15 2008	ISPH	INSPIRE PHARMACEUT ...	YERXA BENJAMIN R	Chf Sci Off & EVP S ...	Buy	M	0.21	14,996	3,149	63,121	48.1 K to 63.1 K (+31.16 %)
Mar 24 2008	ISPH	INSPIRE PHARMACEUT ...	SCHACHLE JOSEPH K	EVP, Chief Commerci ...	Option Exercise	A	3.98	12,000	47,760	12,000
Mar 24 2008	ISPH	INSPIRE PHARMACEUT ...	Spagnardi Joseph M	Senior VP, GC & Sec ...	Option Exercise	A	3.98	10,250	40,795	10,250
Mar 24 2008	ISPH	INSPIRE PHARMACEUT ...	Brazzell Romulus K	Sr. VP, Ophthalmic ...	Option Exercise	A	3.98	10,250	40,795	10,250
Mar 24 2008	ISPH	INSPIRE PHARMACEUT ...	YERXA BENJAMIN R	Chf Sci Off & EVP S ...	Option Exercise	A	3.98	14,000	55,720	14,000
Mar 24 2008	ISPH	INSPIRE PHARMACEUT ...	KELLERMAN DONALD J	Senior VP, Developm ...	Option Exercise	A	3.98	9,750	38,805	9,750
Mar 24 2008	ISPH	INSPIRE PHARMACEUT ...	STAAB THOMAS R II	CFO & Treasurer	Option Exercise	A	3.98	11,250	44,775	11,250
Mar 24 2008	ISPH	INSPIRE PHARMACEUT ...	SHAFFER CHRISTY L	President & CEO	Option Exercise	A	3.98	29,500	117,410	29,500
Nov 15 2007	ISPH	INSPIRE PHARMACEUT ...	Spagnardi Joseph M	Senior VP, GC & Sec ...	Option Exercise	A	6.10	10,250	62,525	10,250
Nov 14 2007	ISPH	INSPIRE PHARMACEUT ...	SHAFFER CHRISTY L	President & CEO	Option Exercise	A	6.10	29,500	179,950	29,500
Nov 14 2007	ISPH	INSPIRE PHARMACEUT ...	SHAFFER CHRISTY L	President & CEO	Sell	S	6.00	2,032	12,192	371,497	373.5 K to 371.5 K (-0.54 %)
Nov 14 2007	ISPH	INSPIRE PHARMACEUT ...	SHAFFER CHRISTY L	President & CEO	Sell	S	6.01	100	601	373,529	373.6 K to 373.5 K (-0.03 %)
Nov 14 2007	ISPH	INSPIRE PHARMACEUT ...	SHAFFER CHRISTY L	President & CEO	Sell	S	6.02	193	1,162	373,629	373.8 K to 373.6 K (-0.05 %)
Nov 14 2007	ISPH	INSPIRE PHARMACEUT ...	SHAFFER CHRISTY L	President & CEO	Sell	S	6.03	675	4,070	373,822	374.5 K to 373.8 K (-0.18 %)
Nov 14 2007	ISPH	INSPIRE PHARMACEUT ...	SHAFFER CHRISTY L	President & CEO	Sell	S	6.04	400	2,416	374,497	374.9 K to 374.5 K (-0.11 %)
Nov 14 2007	ISPH	INSPIRE PHARMACEUT ...	SHAFFER CHRISTY L	President & CEO	Sell	S	6.05	800	4,840	374,897	375.7 K to 374.9 K (-0.21 %)
Nov 14 2007	ISPH	INSPIRE PHARMACEUT ...	SHAFFER CHRISTY L	President & CEO	Sell	S	6.06	500	3,030	375,697	376.2 K to 375.7 K (-0.13 %)
Nov 14 2007	ISPH	INSPIRE PHARMACEUT ...	SHAFFER CHRISTY L	President & CEO	Sell	S	6.07	300	1,821	376,197	376.5 K to 376.2 K (-0.08 %)
Nov 14 2007	ISPH	INSPIRE PHARMACEUT ...	YERXA BENJAMIN R	Chf Sci Off & EVP S ...	Option Exercise	A	6.10	13,250	80,825	13,250
Nov 14 2007	ISPH	INSPIRE PHARMACEUT ...	SCHACHLE JOSEPH K	EVP, Chief Commerci ...	Option Exercise	A	6.10	15,000	91,500	15,000
Nov 14 2007	ISPH	INSPIRE PHARMACEUT ...	STAAB THOMAS R II	CFO & Treasurer	Option Exercise	A	6.10	10,250	62,525	10,250
Nov 14 2007	ISPH	INSPIRE PHARMACEUT ...	KELLERMAN DONALD J	Senior VP, Developm ...	Option Exercise	A	6.10	9,500	57,950	9,500
Nov 14 2007	ISPH	INSPIRE PHARMACEUT ...	Brazzell Romulus K	Sr. VP, Ophthalmic ...	Option Exercise	A	6.10	10,250	62,525	10,250
Nov 01 2007	ISPH	INSPIRE PHARMACEUT ...	LEFF JONATHAN S	Director	Option Exercise	C	0.00	140,186	0	0
Nov 01 2007	ISPH	INSPIRE PHARMACEUT ...	LEFF JONATHAN S	Director	Buy	C	0.00	14,018,600	0	14,018,600	0 to 14 M
Nov 01 2007	ISPH	INSPIRE PHARMACEUT ...	Warburg Pincus Private Equity ...	10% Owner	Option Exercise	C	0.00	140,186	0	0
Nov 01 2007	ISPH	INSPIRE PHARMACEUT ...	Warburg Pincus Private Equity ...	10% Owner	Buy	C	0.00	14,018,600	0	14,018,600	0 to 14 M
Sep 10 2007	ISPH	INSPIRE PHARMACEUT ...	SHAFFER CHRISTY L	President & CEO	Sell	S	6.00	5,000	30,000	376,497	381.5 K to 376.5 K (-1.31 %)
Aug 17 2007	ISPH	INSPIRE PHARMACEUT ...	SHAFFER CHRISTY L	President & CEO	Option Exercise	A	5.81	29,500	171,395	29,500
Aug 17 2007	ISPH	INSPIRE PHARMACEUT ...	BENNETT MARY B	Exec. VP, Operation ...	Option Exercise	A	5.81	10,000	58,100	10,000
Aug 17 2007	ISPH	INSPIRE PHARMACEUT ...	SCHACHLE JOSEPH K	EVP, Chief Commerci ...	Option Exercise	A	5.81	15,000	87,150	15,000
Aug 17 2007	ISPH	INSPIRE PHARMACEUT ...	YERXA BENJAMIN R	Chf Sci Off & EVP S ...	Option Exercise	A	5.81	13,250	76,983	13,250
Aug 17 2007	ISPH	INSPIRE PHARMACEUT ...	STAAB THOMAS R II	CFO & Treasurer	Option Exercise	A	5.81	10,250	59,553	10,250
Aug 17 2007	ISPH	INSPIRE PHARMACEUT ...	KELLERMAN DONALD J	Senior VP, Developm ...	Option Exercise	A	5.81	9,500	55,195	9,500
Aug 17 2007	ISPH	INSPIRE PHARMACEUT ...	Brazzell Romulus K	Sr. VP, Ophthalmic ...	Option Exercise	A	5.81	10,250	59,553	10,250
Aug 17 2007	ISPH	INSPIRE PHARMACEUT ...	Spagnardi Joseph M	Senior VP, GC & Sec ...	Option Exercise	A	5.81	10,250	59,553	10,250
Jun 12 2007	ISPH	INSPIRE PHARMACEUT ...	Hutson Nancy J	Director	Option Exercise	A	5.46	30,000	163,800	30,000
Jun 12 2007	ISPH	INSPIRE PHARMACEUT ...	FREY KIP	Director	Option Exercise	A	5.46	30,000	163,800	30,000
Jun 12 2007	ISPH	INSPIRE PHARMACEUT ...	Kent Richard S	Director	Option Exercise	A	5.46	30,000	163,800	30,000
Jun 12 2007	ISPH	INSPIRE PHARMACEUT ...	LEE KENNETH B JR	Director	Option Exercise	A	5.46	10,000	54,600	10,000
Jun 12 2007	ISPH	INSPIRE PHARMACEUT ...	LEE KENNETH B JR	Director	Option Exercise	A	5.46	30,000	163,800	30,000
Jun 12 2007	ISPH	INSPIRE PHARMACEUT ...	LEE KENNETH B JR	Director	Option Exercise	A	5.46	10,000	54,600	10,000
Jun 12 2007	ISPH	INSPIRE PHARMACEUT ...	LEE KENNETH B JR	Director	Option Exercise	A	5.46	30,000	163,800	30,000
Jun 12 2007	ISPH	INSPIRE PHARMACEUT ...	RINGO WILLIAM R	Director	Option Exercise	A	5.46	30,000	163,800	30,000
May 17 2007	ISPH	INSPIRE PHARMACEUT ...	SHAFFER CHRISTY L	President & CEO	Option Exercise	A	6.35	29,500	187,325	29,500
May 17 2007	ISPH	INSPIRE PHARMACEUT ...	SHAFFER CHRISTY L	President & CEO	Sell	S	6.29	385	2,422	381,497	381.9 K to 381.5 K (-0.10 %)
May 17 2007	ISPH	INSPIRE PHARMACEUT ...	SHAFFER CHRISTY L	President & CEO	Sell	S	6.30	1,215	7,655	381,882	383.1 K to 381.9 K (-0.32 %)
May 17 2007	ISPH	INSPIRE PHARMACEUT ...	SHAFFER CHRISTY L	President & CEO	Sell	S	6.31	2,600	16,406	383,097	385.7 K to 383.1 K (-0.67 %)
May 17 2007	ISPH	INSPIRE PHARMACEUT ...	SHAFFER CHRISTY L	President & CEO	Sell	S	6.32	200	1,264	385,697	385.9 K to 385.7 K (-0.05 %)
May 17 2007	ISPH	INSPIRE PHARMACEUT ...	SHAFFER CHRISTY L	President & CEO	Sell	S	6.34	600	3,804	385,897	386.5 K to 385.9 K (-0.16 %)
May 17 2007	ISPH	INSPIRE PHARMACEUT ...	Spagnardi Joseph M	Senior VP, GC & Sec ...	Option Exercise	A	6.35	10,250	65,088	10,250
May 17 2007	ISPH	INSPIRE PHARMACEUT ...	KELLERMAN DONALD J	Senior VP, Developm ...	Option Exercise	A	6.35	10,000	63,500	10,000
May 17 2007	ISPH	INSPIRE PHARMACEUT ...	STAAB THOMAS R II	CFO & Treasurer	Option Exercise	A	6.35	10,250	65,088	10,250
May 17 2007	ISPH	INSPIRE PHARMACEUT ...	SCHACHLE JOSEPH K	EVP, Chief Commerci ...	Option Exercise	A	6.35	12,500	79,375	12,500
May 17 2007	ISPH	INSPIRE PHARMACEUT ...	Brazzell Romulus K	Sr. VP, Ophthalmic ...	Option Exercise	A	6.35	11,250	71,438	11,250
May 17 2007	ISPH	INSPIRE PHARMACEUT ...	YERXA BENJAMIN R	Chf Sci Off & EVP S ...	Option Exercise	A	6.35	12,500	79,375	12,500
May 17 2007	ISPH	INSPIRE PHARMACEUT ...	BENNETT MARY B	Exec. VP, Operation ...	Option Exercise	A	6.35	13,250	84,138	13,250
May 02 2007	ISPH	INSPIRE PHARMACEUT ...	Flynn James E	10% Owner	Sell	S	7.73	177,129	1,369,792	2,307,449	2.5 M to 2.3 M (-7.13 %)
May 02 2007	ISPH	INSPIRE PHARMACEUT ...	Flynn James E	10% Owner	Sell	S	7.73	134,645	1,041,250	1,754,062	1.9 M to 1.8 M (-7.13 %)
May 02 2007	ISPH	INSPIRE PHARMACEUT ...	Flynn James E	10% Owner	Sell	S	7.73	59,879	463,068	781,151	841 K to 781.2 K (-7.12 %)
May 02 2007	ISPH	INSPIRE PHARMACEUT ...	Flynn James E	10% Owner	Sell	S	7.73	31,677	244,968	413,293	445 K to 413.3 K (-7.12 %)
Mar 23 2007	ISPH	INSPIRE PHARMACEUT ...	Spagnardi Joseph M	Senior VP, GC & Sec ...	Option Exercise	A	6.49	10,250	66,523	10,250
Mar 23 2007	ISPH	INSPIRE PHARMACEUT ...	SHAFFER CHRISTY L	President & CEO	Option Exercise	A	6.30	29,500	185,850	29,500
Mar 23 2007	ISPH	INSPIRE PHARMACEUT ...	BENNETT MARY B	Exec. VP, Operation ...	Option Exercise	A	6.49	13,250	85,993	13,250
Mar 23 2007	ISPH	INSPIRE PHARMACEUT ...	YERXA BENJAMIN R	Chf Sci Off & EVP S ...	Option Exercise	A	6.49	12,500	81,125	12,500
Mar 23 2007	ISPH	INSPIRE PHARMACEUT ...	SCHACHLE JOSEPH K	EVP, Chief Commerci ...	Option Exercise	A	6.49	12,500	81,125	12,500
Mar 23 2007	ISPH	INSPIRE PHARMACEUT ...	KELLERMAN DONALD J	Senior VP, Developm ...	Option Exercise	A	6.49	10,000	64,900	10,000
Mar 23 2007	ISPH	INSPIRE PHARMACEUT ...	STAAB THOMAS R II	CFO & Treasurer	Option Exercise	A	6.49	10,250	66,523	10,250
Mar 23 2007	ISPH	INSPIRE PHARMACEUT ...	Brazzell Romulus K	Sr. VP, Ophthalmic ...	Option Exercise	A	6.49	11,250	73,013	11,250
Mar 14 2007	ISPH	INSPIRE PHARMACEUT ...	SHAFFER CHRISTY L	President & CEO	Option Exercise	M	0.42	114,285	48,000	0
Mar 14 2007	ISPH	INSPIRE PHARMACEUT ...	SHAFFER CHRISTY L	President & CEO	Buy	M	0.42	114,285	48,000	386,497	272.2 K to 386.5 K (+41.98 %)
Mar 14 2007	ISPH	INSPIRE PHARMACEUT ...	STAAB THOMAS R II	CFO & Treasurer	Option Exercise	M	5.25	2,000	10,500	13,000
Mar 14 2007	ISPH	INSPIRE PHARMACEUT ...	STAAB THOMAS R II	CFO & Treasurer	Buy	M	5.25	2,000	10,500	22,000	20 K to 22 K (+10.00 %)
Mar 13 2007	ISPH	INSPIRE PHARMACEUT ...	Hutson Nancy J	Director	Buy	P	6.35	7,800	49,529	7,800	0 to 7.8 K
Jan 18 2007	ISPH	INSPIRE PHARMACEUT ...	GREAT POINT PARTNERS LLC	10% Owner	Sell	S	7.31	230,000	1,680,610	1,888,300	2.1 M to 1.9 M (-10.86 %)
Jan 18 2007	ISPH	INSPIRE PHARMACEUT ...	GREAT POINT PARTNERS LLC	10% Owner	Sell	S	7.31	270,000	1,972,890	2,216,700	2.5 M to 2.2 M (-10.86 %)
Oct 30 2006	ISPH	INSPIRE PHARMACEUT ...	Hutson Nancy J	Director	Option Exercise	A	5.40	1,333	7,198	1,333
Oct 30 2006	ISPH	INSPIRE PHARMACEUT ...	Hutson Nancy J	Director	Option Exercise	A	5.40	17,778	96,001	17,778
Aug 31 2006	ISPH	INSPIRE PHARMACEUT ...	SHAFFER CHRISTY L	President & CEO	Option Exercise	A	5.00	59,000	295,000	59,000
Sep 01 2006	ISPH	INSPIRE PHARMACEUT ...	STAAB THOMAS R II	CFO & Treasurer	Option Exercise	A	5.00	20,500	102,500	20,500
Aug 31 2006	ISPH	INSPIRE PHARMACEUT ...	YERXA BENJAMIN R	Chief, Sci. Op. & A ...	Option Exercise	A	5.00	25,000	125,000	25,000
Aug 31 2006	ISPH	INSPIRE PHARMACEUT ...	BENNETT MARY B	Exec. VP, Operation ...	Option Exercise	A	5.00	26,500	132,500	26,500
Aug 31 2006	ISPH	INSPIRE PHARMACEUT ...	SCHACHLE JOSEPH K	Sr. VP, Marketing & ...	Option Exercise	A	5.00	20,500	102,500	20,500
Aug 31 2006	ISPH	INSPIRE PHARMACEUT ...	KELLERMAN DONALD J	Senior VP, Developm ...	Option Exercise	A	5.00	19,500	97,500	19,500
Aug 31 2006	ISPH	INSPIRE PHARMACEUT ...	Brazzell Romulus K	Sr. VP, Ophthalmic ...	Option Exercise	A	5.00	20,500	102,500	20,500
Aug 31 2006	ISPH	INSPIRE PHARMACEUT ...	Spagnardi Joseph M	Senior VP, GC & Sec ...	Option Exercise	A	5.00	20,500	102,500	20,500
Jul 25 2006	ISPH	INSPIRE PHARMACEUT ...	BENNETT MARY B	Exec. VP, Operation ...	Grant	A	0.00	25,000	0	30,000	5 K to 30 K (+500.00 %)
Jul 25 2006	ISPH	INSPIRE PHARMACEUT ...	SHAFFER CHRISTY L	President & CEO	Grant	A	0.00	50,000	0	272,212	222.2 K to 272.2 K (+22.50 %)
Jul 25 2006	ISPH	INSPIRE PHARMACEUT ...	YERXA BENJAMIN R	Chief, Sci. Op. & A ...	Grant	A	0.00	20,000	0	48,125	28.1 K to 48.1 K (+71.11 %)
Jul 25 2006	ISPH	INSPIRE PHARMACEUT ...	KELLERMAN DONALD J	Senior VP, Developm ...	Grant	A	0.00	20,000	0	20,000	0 to 20 K
Jul 25 2006	ISPH	INSPIRE PHARMACEUT ...	SCHACHLE JOSEPH K	Sr. VP, Marketing & ...	Grant	A	0.00	20,000	0	20,150	150 to 20.2 K (+13,333.33 %)
Jul 25 2006	ISPH	INSPIRE PHARMACEUT ...	Brazzell Romulus K	Sr. VP, Ophthalmic ...	Grant	A	0.00	20,000	0	20,000	0 to 20 K
Jul 25 2006	ISPH	INSPIRE PHARMACEUT ...	Spagnardi Joseph M	Senior VP, GC & Sec ...	Grant	A	0.00	20,000	0	20,000	0 to 20 K
Jul 25 2006	ISPH	INSPIRE PHARMACEUT ...	STAAB THOMAS R II	CFO & Treasurer	Grant	A	0.00	20,000	0	20,000	0 to 20 K
Jun 30 2006	ISPH	INSPIRE PHARMACEUT ...	GREAT POINT PARTNERS LLC	10% Owner	Buy	P	4.03	163,800	660,114	2,394,600	2.2 M to 2.4 M (+7.34 %)
Jun 30 2006	ISPH	INSPIRE PHARMACEUT ...	GREAT POINT PARTNERS LLC	10% Owner	Buy	P	4.02	5,200	20,904	2,230,800	2.2 M to 2.2 M (+0.23 %)
Jun 30 2006	ISPH	INSPIRE PHARMACEUT ...	GREAT POINT PARTNERS LLC	10% Owner	Buy	P	4.03	151,200	609,336	2,210,400	2.1 M to 2.2 M (+7.34 %)
Jun 30 2006	ISPH	INSPIRE PHARMACEUT ...	GREAT POINT PARTNERS LLC	10% Owner	Buy	P	4.02	4,800	19,296	2,059,200	2.1 M to 2.1 M (+0.23 %)
Jun 14 2006	ISPH	INSPIRE PHARMACEUT ...	HOLMER ALAN F	Director	Option Exercise	A	4.39	2,000	8,780	2,000
Jun 14 2006	ISPH	INSPIRE PHARMACEUT ...	HOLMER ALAN F	Director	Option Exercise	A	4.39	2,000	8,780	2,000
Jun 14 2006	ISPH	INSPIRE PHARMACEUT ...	HOLMER ALAN F	Director	Option Exercise	A	4.39	20,000	87,800	20,000
Jun 14 2006	ISPH	INSPIRE PHARMACEUT ...	RINGO WILLIAM R	Director	Option Exercise	A	4.39	4,000	17,560	4,000
Jun 14 2006	ISPH	INSPIRE PHARMACEUT ...	RINGO WILLIAM R	Director	Option Exercise	A	4.39	20,000	87,800	20,000
Jun 14 2006	ISPH	INSPIRE PHARMACEUT ...	FREY KIP	Director	Option Exercise	A	4.39	2,000	8,780	2,000
Jun 14 2006	ISPH	INSPIRE PHARMACEUT ...	FREY KIP	Director	Option Exercise	A	4.39	4,000	17,560	4,000
Jun 14 2006	ISPH	INSPIRE PHARMACEUT ...	FREY KIP	Director	Option Exercise	A	4.39	10,000	43,900	10,000
Jun 14 2006	ISPH	INSPIRE PHARMACEUT ...	Kent Richard S	Director	Option Exercise	A	4.39	2,000	8,780	2,000
Jun 14 2006	ISPH	INSPIRE PHARMACEUT ...	Kent Richard S	Director	Option Exercise	A	4.39	2,000	8,780	2,000
Jun 14 2006	ISPH	INSPIRE PHARMACEUT ...	Kent Richard S	Director	Option Exercise	A	4.39	10,000	43,900	10,000
May 11 2006	ISPH	INSPIRE PHARMACEUT ...	Flynn James E	10% Owner	Buy	P	4.84	88,844	430,120	841,030	752.2 K to 841 K (+11.81 %)
May 11 2006	ISPH	INSPIRE PHARMACEUT ...	Flynn James E	10% Owner	Buy	P	4.84	44,156	213,772	444,970	400.8 K to 445 K (+11.02 %)
May 11 2006	ISPH	INSPIRE PHARMACEUT ...	Flynn James E	10% Owner	Buy	P	4.87	44,756	217,854	752,186	707.4 K to 752.2 K (+6.33 %)
May 11 2006	ISPH	INSPIRE PHARMACEUT ...	Flynn James E	10% Owner	Buy	P	4.87	22,244	108,275	400,814	378.6 K to 400.8 K (+5.88 %)
Jun 14 2006	ISPH	INSPIRE PHARMACEUT ...	LEE KENNETH B JR	Director	Option Exercise	A	4.39	4,000	17,560	4,000
Jun 14 2006	ISPH	INSPIRE PHARMACEUT ...	LEE KENNETH B JR	Director	Option Exercise	A	4.39	2,000	8,780	2,000
Jun 14 2006	ISPH	INSPIRE PHARMACEUT ...	LEE KENNETH B JR	Director	Option Exercise	A	4.39	4,000	17,560	4,000
Jun 14 2006	ISPH	INSPIRE PHARMACEUT ...	LEE KENNETH B JR	Director	Option Exercise	A	4.39	10,000	43,900	10,000
May 04 2006	ISPH	INSPIRE PHARMACEUT ...	Flynn James E	10% Owner	Buy	P	4.85	49,706	241,074	707,430	657.7 K to 707.4 K (+7.56 %)
May 04 2006	ISPH	INSPIRE PHARMACEUT ...	Flynn James E	10% Owner	Buy	P	4.85	24,704	119,814	378,570	353.9 K to 378.6 K (+6.98 %)
May 08 2006	ISPH	INSPIRE PHARMACEUT ...	Spagnardi Joseph M	Senior VP, GC & Sec ...	Option Exercise	A	4.85	7,000	33,950	7,000
Apr 13 2006	ISPH	INSPIRE PHARMACEUT ...	Flynn James E	10% Owner	Buy	P	4.85	6,681	32,403	657,724	651 K to 657.7 K (+1.03 %)
Apr 13 2006	ISPH	INSPIRE PHARMACEUT ...	Flynn James E	10% Owner	Buy	P	4.85	3,319	16,097	353,866	350.5 K to 353.9 K (+0.95 %)
Apr 13 2006	ISPH	INSPIRE PHARMACEUT ...	Flynn James E	10% Owner	Buy	P	4.85	51,661	250,556	2,484,578	2.4 M to 2.5 M (+2.12 %)
Apr 13 2006	ISPH	INSPIRE PHARMACEUT ...	Flynn James E	10% Owner	Buy	P	4.85	38,339	185,944	1,888,707	1.9 M to 1.9 M (+2.07 %)
Mar 09 2006	ISPH	INSPIRE PHARMACEUT ...	Flynn James E	10% Owner	Buy	P	4.95	53,430	264,238	651,043	597.6 K to 651 K (+8.94 %)
Mar 09 2006	ISPH	INSPIRE PHARMACEUT ...	Flynn James E	10% Owner	Buy	P	4.95	28,770	142,282	350,547	321.8 K to 350.5 K (+8.94 %)
Feb 24 2006	ISPH	INSPIRE PHARMACEUT ...	Flynn James E	10% Owner	Buy	P	4.74	1,024	4,854	597,613	596.6 K to 597.6 K (+0.17 %)
Feb 24 2006	ISPH	INSPIRE PHARMACEUT ...	Flynn James E	10% Owner	Buy	P	4.75	23,267	110,525	596,589	573.3 K to 596.6 K (+4.06 %)
Feb 24 2006	ISPH	INSPIRE PHARMACEUT ...	Flynn James E	10% Owner	Buy	P	4.55	33,032	150,296	573,322	540.3 K to 573.3 K (+6.11 %)
Feb 24 2006	ISPH	INSPIRE PHARMACEUT ...	Flynn James E	10% Owner	Buy	P	4.74	551	2,612	321,777	321.2 K to 321.8 K (+0.17 %)
Feb 24 2006	ISPH	INSPIRE PHARMACEUT ...	Flynn James E	10% Owner	Buy	P	4.75	12,527	59,507	321,226	308.7 K to 321.2 K (+4.06 %)
Feb 24 2006	ISPH	INSPIRE PHARMACEUT ...	Flynn James E	10% Owner	Buy	P	4.55	17,785	80,922	308,699	290.9 K to 308.7 K (+6.11 %)
Feb 24 2006	ISPH	INSPIRE PHARMACEUT ...	Flynn James E	10% Owner	Buy	P	4.74	4,388	20,799	2,431,397	2.4 M to 2.4 M (+0.18 %)
Feb 24 2006	ISPH	INSPIRE PHARMACEUT ...	Flynn James E	10% Owner	Buy	P	4.72	85,200	402,144	2,427,009	2.3 M to 2.4 M (+3.64 %)
Feb 24 2006	ISPH	INSPIRE PHARMACEUT ...	Flynn James E	10% Owner	Buy	P	4.75	99,694	473,576	2,341,809	2.2 M to 2.3 M (+4.45 %)
Feb 24 2006	ISPH	INSPIRE PHARMACEUT ...	Flynn James E	10% Owner	Buy	P	4.55	141,536	643,989	2,242,115	2.1 M to 2.2 M (+6.74 %)
Feb 24 2006	ISPH	INSPIRE PHARMACEUT ...	Flynn James E	10% Owner	Buy	P	4.74	3,337	15,817	1,849,213	1.8 M to 1.8 M (+0.18 %)
Feb 24 2006	ISPH	INSPIRE PHARMACEUT ...	Flynn James E	10% Owner	Buy	P	4.72	64,800	305,856	1,845,876	1.8 M to 1.8 M (+3.64 %)
Feb 24 2006	ISPH	INSPIRE PHARMACEUT ...	Flynn James E	10% Owner	Buy	P	4.75	75,822	360,177	1,781,076	1.7 M to 1.8 M (+4.45 %)
Feb 24 2006	ISPH	INSPIRE PHARMACEUT ...	Flynn James E	10% Owner	Buy	P	4.55	107,647	489,794	1,705,254	1.6 M to 1.7 M (+6.74 %)
Mar 30 2006	ISPH	INSPIRE PHARMACEUT ...	Flynn James E	10% Owner	Buy	P	4.78	1,520	7,266	2,432,917	2.4 M to 2.4 M (+0.06 %)
Mar 30 2006	ISPH	INSPIRE PHARMACEUT ...	Flynn James E	10% Owner	Buy	P	4.78	1,155	5,521	1,850,368	1.8 M to 1.9 M (+0.06 %)

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